Protein Alignment Cyp4e2 and Cyp3a59

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001098630.1
• Gene: Cyp3a59 / 100041449
• MGIID: 3769707
• Length: 503
• Species: Mus musculus
• Alignment Length: 513
• Identity: 124/513 - (24%)
• Similarity: 234/513 - (45%)
• Gaps: 93/513 - (18%)

  Fly    35 GPRGLPLMGNAHQMGKNPSEILDTVFSW-----------WHQYGKDNFVFWIGTYSNVLVTSSKY 88
            ||:.|||.|              |:|::           :.:||| .:.|::|....:.:...:.
Mouse    40 GPKPLPLFG--------------TIFNYFDGMWKFDEDCYKKYGK-IWGFYVGPKPILAIMDPEI 89

  Fly    89 LEFILSSQ--TLITKSDIYQLTHPWLG-LGLL-----TSTGSKWHKHRKMITPAFHFNILQDFHE 145
            ::.:|..:  ::.|       ..|.|| :|.|     .|...:|.:.|.:::|.|....|::...
Mouse    90 IKIVLVKECYSVFT-------NRPTLGPVGFLKKSITISEDEEWKRLRTLLSPTFTSGKLKEMFP 147

  Fly   146 VMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVSINAMENRSSSIVQAFKDMCY 210
            :|.:.....:::|:.........:.::.....::|||..|:.||:|:::.|..:..||..|.:
Mouse   148 IMRQYGDILVRNLRREEEKGEPINMKDIFGAYSMDVITGTSFGVNIDSLNNPQNPFVQKTKKI-- 210

  Fly   211 NINMRAFHPLKRNELLYR-LAPDYPAYSRTL--KTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFT 272
             :..:.|.|...:.:|:. |.|.|...:.::  :...:|..:.: ||::..:..:...|..|
Mouse   211 -LKFKIFDPFLLSTILFPFLTPIYEMLNLSIFPRDSMNFFKKFV-KRMKKERLASKQKNRVD--- 270

  Fly   273 RKKMAFLDTLLSSTIDGRPLNSK-----------ELYEEVSTFMFEGHDTTTSGVSFAVYLLSRH 326
                 ||..::::.      |||           |:..:...|:|.|:|.|::.:|..:|.|:.|
Mouse   271 -----FLQLMMNTQ------NSKGQESQKALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATH 324

  Fly   327 QDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGD 391
            .|.|:||..|....:.|.   ...|:..:..|:|||:.:.|:.|:||:...:.|.::||..|:|.
Mouse   325 PDVQKKLQDEIDRTLPNK---APVTYDALMDMEYLDMVVNESLRLYPTAIRLERVSKKDVEINGV 386

  Fly   392 LVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPG---PFEYVPFSAGPRNCIGQKFALLE 453
            .:||||.:.:.:..|..|.:.:.:|.:|.|.||..|..|   |:.|:||..|||||:..:|||:.
Mouse   387 FIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKENEGNIDPYIYMPFGNGPRNCLDMRFALIS 451

  Fly   454 IKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVLT 511
            :|..|..:::||.|.|..:          |.|.|    :..|:|......||:..|::
Mouse   452 MKLAVIGVLQNFTVQPCEE----------TQIPL----KISREPVFQPEKPIILKVVS 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	114/469 (24%)
Cyp3a59	NP_001098630.1	CYP3A	67..492	CDD:410743	115/467 (25%)