Protein Alignment Cyp4e2 and Cyp3a41b

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001098629.1
• Gene: Cyp3a41b / 100041375
• MGIID: 3714859
• Length: 504
• Species: Mus musculus
• Alignment Length: 511
• Identity: 118/511 - (23%)
• Similarity: 245/511 - (47%)
• Gaps: 73/511 - (14%)

  Fly     6 YIFLALPLLLVAYLELST---FRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWW---- 63
            ::.||:.|:|:......|   |:::.:    .||:.||.:|.          :|:.....|
Mouse    12 WVLLAIILVLLYRYGTRTHGLFKKQGI----PGPKPLPFLGT----------VLNYYKGLWKFDM 62

  Fly    64 ---HQYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLT-----ST 120
               .:||| .:..:.|.....::|..:.::.:|..:..    .::.....:..:|:::     |.
Mouse    63 ECYEKYGK-TWGLFDGQMPLFVITDPEMIKNVLVKECF----SVFTNRREFGPVGIMSKAISISK 122

  Fly   121 GSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDT 185
            ..:|.::|.:::|.|....|::...|:.:.....:|:|...|........::.....::|||..|
Mouse   123 DEEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEKGKPVTMKDVLGAYSIDVITST 187

  Fly   186 AMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYR-LAPDYPAYS------RTLKTL 243
            :.||:::::.|.....|:..|.:   :.:..|.||..:.:|:. |.|.|...:      .:::..
Mouse   188 SFGVNVDSLNNPEDPFVEKAKGI---LRVDFFDPLVFSVVLFPFLTPVYEMLNICMFPKDSIEFF 249

  Fly   244 QDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDG------RPLNSKELYEEVS 302
            :.|.|.:...|:::.:             :.::.||..::::..:.      :.|:..|:..:..
Mouse   250 KKFVNRMKESRLDSKQ-------------KHRVDFLQLMMNAHNNSKDKDSHKALSDMEITAQSI 301

  Fly   303 TFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKE 367
            .|:|.|::||:|.:||.:|.|:.|.|.|:||.:|..|.:.|.   ...|:..:.:|:|||:.:.|
Mouse   302 VFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNK---APPTYDTVMEMEYLDMVLNE 363

  Fly   368 AQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPG-- 430
            ..|:||....:.||.:||..::|..:|||:|:.:....|.::.:.:.:|.:|:||||..|..|
Mouse   364 TLRLYPIGNRLERFCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWPEPEEFQPERFSKENKGSI 428

  Fly   431 -PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELV----SKDGYI 481
             |:.|:||..|||||||.:||.:.:|..::|:::||...|..:..:    |:.|.:
Mouse   429 DPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQIPLKLSRQGLL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	103/439 (23%)
Cyp3a41b	NP_001098629.1	CYP3A	67..493	CDD:410743	105/442 (24%)