DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and ERG5

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_013728.1	Gene:	ERG5 / 855029	SGDID:	S000004617	Length:	538	Species:	Saccharomyces cerevisiae

Alignment Length:	495	Identity:	107/495 - (21%)
Similarity:	202/495 - (40%)	Gaps:	82/495 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FLIAIAIILATILVFKGVRIFNYIDHMAGIME--MIPGP--TPYPFVGNLFQFGLKPAEYPKKVL 62
            :|...|.::..:||:         |.:|..::  .|.||  ..:|.:|...: .|.|     |..
Yeast    45 YLKIFATLICILLVW---------DQVAYQIKKGSIAGPKFKFWPIIGPFLE-SLDP-----KFE 94

  Fly    63 QYCRKYDFQGFRSLV--FLQYHMMLSDPAEIQNILSSSSLL---YKEHLYSFLRP--WLGDGLLT 120
            :|..|: ..|..|.|  |.::.::.|.....:.||.||..:   ..:.....|||  |     :.
Yeast    95 EYKAKW-ASGPLSCVSIFHKFVVIASTRDLARKILQSSKFVKPCVVDVAVKILRPCNW-----VF 153

  Fly   121 SSGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQ----EVF--DAQELVAKC 179
            ..|.....::|.....|.:.|:..||..:.:...:::.|...||...    :||  :.:|::...
Yeast   154 LDGKAHTDYRKSLNGLFTKQALAQYLPSLEQIMDKYMDKFVRLSKENNYEPQVFFHEMREILCAL 218

  Fly   180 TLDIVCENATGQDSSSLNGETSDLHGAIKDLCDVVQERTFSI-VKRFDALFRLT-SYYMKQRRAL 242
            :|:..|.|...:|.             ::.:.|.....|.:: :..|..:...| ::|.|:...:
Yeast   219 SLNSFCGNYITEDQ-------------VRKIADDYYLVTAALELVNFPIIIPYTKTWYGKKTADM 270

  Fly   243 SLLRSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLLTAKLDGK------------VLKEREI 295
            ::.       |.:...|:|.::....|:|:  ..:|.......|.|            ....:||
Yeast   271 AMK-------IFENCAQMAKDHIAAGGKPV--CVMDAWCKLMHDAKNSNDDDSRIYHREFTNKEI 326

  Fly   296 IEEVSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLEL 360
            .|.|.||:|...|..::...:....::...::..|..|||..:...:.:.|.:|..:::|.|..:
Yeast   327 SEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEKMKYTNM 391

  Fly   361 IIRETLRLYP---SVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFE 422
            :|:||||..|   .||.:.:.| .|:..|.| ..|...:|..|....::.:.:::|..|.|||:.
Yeast   392 VIKETLRYRPPVLMVPYVVKKN-FPVSPNYT-APKGAMLIPTLYPALHDPEVYENPDEFIPERWV 454

  Fly   423 NPTGNVGIEAFKS-VPFSAGPRRCIAEKFAMYQMKALLSQ 461
            .  |:...||.|: :.|..||..|:.:.:.|....|||.:
Yeast   455 E--GSKASEAKKNWLVFGCGPHVCLGQTYVMITFAALLGK 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	100/459 (22%)
ERG5	NP_013728.1	CYP61_CYP710	103..522	CDD:410703	91/421 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I1557
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	120	1.000	Inparanoid score	I1313
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
TreeFam	0	0.000	Not matched by this tool.
	3	3.050