Protein Alignment Cyp4ad1 and CYP4F2

DIOPT Version :9

• Sequence 1: NP_610380.1
• Gene: Cyp4ad1 / 35821
• FlyBaseID: FBgn0033292
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 154/538 - (28%)
• Similarity: 263/538 - (48%)
• Gaps: 68/538 - (12%)

  Fly     1 MFLIAIAIILATILVF--------KGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLF---QFGLKP 54
            :.|:..:.:||.:|.:        :.:|.|                 |.|...|.|   |..:.|
Human    22 LLLVGASWLLAHVLAWTYAFYDNCRRLRCF-----------------PQPPRRNWFWGHQGMVNP 69

  Fly    55 AEYPKKVL-QYCRKYDFQGFRSLVF-LQYHMMLSDPAEIQNILSSSSLL--YKEHLYSFLRPWLG 115
            .|...:|| |....|. |||:..:. :...:.|..|..|::::::|:.:  ..:..||||.||||
Human    70 TEEGMRVLTQLVATYP-QGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLG 133

  Fly   116 DGLLTSSGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVL-SDTQEVFDAQELVAKC 179
            ||||.|:|.:|.:|:::..|||..:.::.|:::.:.:......|..:| |:.....|..|.::..
Human   134 DGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLM 198

  Fly   180 TLDIVCENATGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSL 244
            |||.: :.......|....:.|:...||.:|..:|.:|...|:...|.|:.||....:.|||..|
Human   199 TLDSL-QKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRL 262

  Fly   245 LRSELNRIISQRRHQLAAENTCQ--QGQPINK--PFLDVLLTAK-LDGKVLKEREIIEEVSTFIF 304
            :....:.:|.:||..|.::....  |.:..:|  .|:||||.:| .|||.|.:.:|..|..||:|
Human   263 VHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMF 327

  Fly   305 TGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLY 369
            .|||..|:.:|:.||.|::|.|.|::..:|.:.:..:....|.:...|..:.:|.:.::|:|||:
Human   328 EGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLH 392

  Fly   370 PSVPLIARTNRNPIDI-NGTKVAKCTTVIMCLIAM---GYNEKYFDDPCTFRPERFENPTGNVGI 430
            |.||:|:|.....|.: :|..:.|   .|:|||::   .:|...:.||..:.|.||: |......
Human   393 PPVPVISRHVTQDIVLPDGRVIPK---GIICLISVFGTHHNPAVWPDPEVYDPFRFD-PENIKER 453

  Fly   431 EAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDP 495
            .....:|||||||.||.:.|||.:||.:|:..|.||.:||          ||:          :|
Human   454 SPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLP----------DHT----------EP 498

  Fly   496 VLNIRVTLKSENGIQIRL 513
            .....:.|::|.|:.:|:
Human   499 RRKPELVLRAEGGLWLRV 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	139/450 (31%)
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	8/51 (16%)
		p450	52..515	CDD:365848	147/488 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154776
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650