DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_077764.2	Gene:	Cyp4f18 / 72054	MGIID:	1919304	Length:	524	Species:	Mus musculus

Alignment Length:	440	Identity:	128/440 - (29%)
Similarity:	217/440 - (49%)	Gaps:	41/440 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 PAEIQNILSSSSLLYKEH--LYSFLRPWLGDGLLTSSGARWLKHQKLYAPAFERSAIEGYLRVVH 150
            ||.|:.::.:.:|:..:.  .|.||:||||||||.|:|.:|.:|:::..|||..:.::.|::|.:
Mouse   104 PAFIKPVVLAPALVAPKDTVFYRFLKPWLGDGLLMSTGDKWSRHRRMLTPAFHFNILKPYVKVFN 168

  Fly   151 RTGGQFVQKLDVLSDTQEVF-DAQELVAKCTLDIVCENATGQDSSSLNGETSDLHGAIKDLCDVV 214
            .:......|...|:.....: :..|.::..|||.: :.......|:...:.|:...||.:|..:|
Mouse   169 DSTNIMHAKWQRLASKGSAYLNMFEHISLMTLDSL-QKCVFSFDSNCQEKPSEYITAILELSTLV 232

  Fly   215 QERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELNRIISQRRHQLAAENTCQQGQPINK----- 274
            ..|...::...|..:.||...|:.|:|..|:....:.:|.:||..|..    |.|..:.|
Mouse   233 ARRHQRLLLHVDLFYYLTHDGMRFRKACRLVHDFTDAVIRERRRTLLD----QGGVDVLKAKAKA 293

  Fly   275 ---PFLDVLLTAKLD-GKVLKEREIIEEVSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQ 335
               .|:||||.:|.: ||.|.:.:|..|..||:|.|||..|:.:|:.||.|:||.|.|::..:|.
Mouse   294 KTLDFIDVLLLSKDEHGKALSDEDIRAEADTFMFGGHDTTASGLSWILYNLARHPEYQERCRQEV 358

  Fly   336 RRIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTNRNPIDI-NGTKVAKCTTVIMC 399
            |.:..:....|.:...|.|:.:|.:.|:|:|||:|.|..|:|.....|.: :|..:.|.....:.
Mouse   359 RELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTAISRCCTQDIVLPDGRVIPKGVISRIS 423

  Fly   400 LIAMGYNEKYFDDPCTFRPERFENPTGNV-GIEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLL 463
            :....:|...:.||..:.|.||:  ..|| |......:|||||||.||.:.|||.:||..|:..|
Mouse   424 IFGTHHNPAVWPDPEVYDPFRFD--ADNVKGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTL 486

  Fly   464 RRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLKSENGIQIRL 513
            .||.:||                    .:.:|.....:.|::|.|:.:::
Mouse   487 LRFRVLP--------------------DDKEPRRKPELILRAEGGLWLKV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	122/395 (31%)
Cyp4f18	NP_077764.2	p450	52..516	CDD:365848	128/438 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845241
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650