DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and cyp46a1.3

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001038763.1	Gene:	cyp46a1.3 / 692332	ZFINID:	ZDB-GENE-060519-40	Length:	491	Species:	Danio rerio

Alignment Length:	498	Identity:	128/498 - (25%)
Similarity:	206/498 - (41%)	Gaps:	82/498 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPF-VGNLFQFG--LKPAEYPKKVL-----QY 64
            ::.|..:||....:  ||..:....:.||||....| :|::....  .|...:...:|     :|
Zfish    13 LLSAVFVVFLAYCL--YIHQVHQKYDHIPGPPRDNFLLGHIPTINRVTKSERHMNDLLLIWAEKY 75

  Fly    65 CRKYDFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLL-----YKEHLYSFLRPWLGDGLLTSSGA 124
            ...|....|. .|.:..|.    |...:.|:.|...|     ||.....|.:.:||.||:|::..
Zfish    76 GPVYRLNSFH-YVIINVHC----PEATKTIMMSPKYLKDPFIYKRLFGLFGKRFLGYGLVTATDH 135

  Fly   125 R-WLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENA 188
            . |.:.:::..|||..|.:.|.:...:....:.:.||:.::..:......:||...||||:|:.|
Zfish   136 DIWYRQRRIMDPAFSSSYLRGLISTFNEMSERLMDKLEEMAINKTPAVMHDLVNCVTLDIICKVA 200

  Fly   189 TGQDSSSLNGETSD---------LHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALS- 243
            .|.| .:|..:|.:         |.|.:.||.|                 ....::.|..:|:.
Zfish   201 FGVD-LNLFKQTDNPFQQAIEQCLQGMVLDLRD-----------------PFCKFFPKNWKAIQE 247

  Fly   244 ------LLRSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLLTAKLDGKV--LKERE-IIEEV 299
                  |||....:.|..|:      ...:.|:.:....|..:|....:.||  .|:.| :::..
Zfish   248 TKGATVLLRKTGEQWIQNRK------TAVEIGEDVPNDILTQILKTAKEEKVNNTKDHEQMLDNF 306

  Fly   300 STFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLA--RLDQMHYLELII 362
            .||...|.:..|..:||.:..|.||.||.::|..|...:.|.    :.|::  .|.:..||..::
Zfish   307 VTFFIAGQETTANQLSFAIMELGRHPEIYKRAKAEVDEVLGT----KRDISYEDLGKFTYLSQVL 367

  Fly   363 RETLRLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGN 427
            :|||||||:.|...|.....:.|||.|:....:||.........||:|.||..|.||||     |
Zfish   368 KETLRLYPTAPGTNRWLHEDMVINGIKIPGGISVIFSSYVAQRLEKHFKDPLKFDPERF-----N 427

  Fly   428 VGIEA--FKSVPFSAGPRRCIAEKF-----AMYQMKALLSQLL 463
            |....  :...|||.|||.|:.:.|     |...:..||:|||
Zfish   428 VNAPKPYYCYYPFSLGPRSCLGQVFSQATPAEGALAQLLTQLL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	122/470 (26%)
cyp46a1.3	NP_001038763.1	p450	39..452	CDD:278495	115/450 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820