DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and Cyp4a31

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_964002.2	Gene:	Cyp4a31 / 666168	MGIID:	3028580	Length:	509	Species:	Mus musculus

Alignment Length:	538	Identity:	144/538 - (26%)
Similarity:	253/538 - (47%)	Gaps:	72/538 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FLIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGN---------------LFQFG 51
            ||...::....:|:.|.|:::.:...:...::..|.|..:.|.|:               :..|
Mouse    18 FLQVASVFCLLLLLVKAVQVYLHRKWLLKALQQFPSPPFHWFFGHEQFKGDQELQEIVSCIENF- 81

  Fly    52 LKPAEYPKKVLQYCRKYDFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEHLYSFLRPWLGD 116
              |:.:|:.         |.|.::      ::.:.||..::.||..|. ......|..|.||:|.
Mouse    82 --PSAFPRW---------FWGSKA------YLTVYDPDYMKVILGRSD-PKANGAYRLLAPWIGY 128

  Fly   117 GLLTSSGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTL 181
            |||..:|..|.:|:|:..|||....::.|::.:..:....:.|.:.|:......:..:.::..||
Mouse   129 GLLLLNGQSWFQHRKMLTPAFHYDILKTYVKNMADSIRLMLDKWERLAGQDSSIEIFQHISLMTL 193

  Fly   182 DIVCENA-TGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLL 245
            |.|.:.| :.:.|..::|.......||.||.::|..|..::..:.|.:::|:|......:|..|.
Mouse   194 DTVMKCAFSHKGSVQVDGNYKTYLQAIGDLNNLVHSRVRNMFHQNDTIYKLSSNGRLSNQACQLA 258

  Fly   246 RSELNRIISQRRHQLAAENTCQQGQPINK----PFLDVLLTAKLDGK-VLKEREIIEEVSTFIFT 305
            ....:.:|..|:.||..|...:.   |.|    .|||:||.|:::.: .:.::::..||.||:..
Mouse   259 HDHTDGVIKMRKDQLQDEGELEN---IKKKRRLDFLDILLFARMENEDSMSDKDLRAEVDTFMIE 320

  Fly   306 GHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYP 370
            |||..|:.:|:..|.|:.|.|.||:..||.:.:.|:..:...|  .|||:.|..:.|:|.|||||
Mouse   321 GHDTTASGVSWIFYALATHPEHQQRCREEVQSLLGDGSSITWD--HLDQIPYTTMCIKEALRLYP 383

  Fly   371 SVPLIARTNRNPIDI-NGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERF--ENPTGNVGIEA 432
            .||.|.|.....:.. :|..:.|...|.:.:..:.:|.|.:.:|..|.|.||  ::|.     .:
Mouse   384 PVPSIGRELSTSVTFPDGCSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPR-----HS 443

  Fly   433 FKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVL 497
            ...:|||.|.|.||.::|||.::|.:::..|.|||:||          |.:|   ||.|
Mouse   444 HSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLP----------DPTR---VPMS------ 489

  Fly   498 NIRVTLKSENGIQIRLRK 515
            ..|..|||:|||.:.|:|
Mouse   490 LARFVLKSKNGIYLHLKK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	123/457 (27%)
Cyp4a31	NP_964002.2	p450	52..503	CDD:278495	137/498 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845130
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650