DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	516	Identity:	121/516 - (23%)
Similarity:	225/516 - (43%)	Gaps:	81/516 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FLIAIAIILATILVFKGVRIFNYIDHMAGIMEM--IPGPTPYPFVGNLFQFGLK-----PAEYPK 59
            |.:...:::||.||.    ::.|..|...:.:.  ||||||.||:|.:. |.|:     ..|..:
Human     7 FAMETWVLVATSLVL----LYIYGTHSHKLFKKLGIPGPTPLPFLGTIL-FYLRGLWNFDRECNE 66

  Fly    60 KVLQYCRKYDFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEHLYSF------LRP--WLGD 116
            |..:....|:.|        |..:::.||..|:.:      |.|| .||.      |.|  :|..
Human    67 KYGEMWGLYEGQ--------QPMLVIMDPDMIKTV------LVKE-CYSVFTNQMPLGPMGFLKS 116

  Fly   117 GLLTSSGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTL 181
            .|..:....|.:.:.|.:|||.....:..:.::.:.|...|:.|...::..:..:.::.....|:
Human   117 ALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTM 181

  Fly   182 DIVCENATGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIV--------KRFDALF-----RLTS 233
            |::.....|.:..|||.........:|.|..:.....|.::        ..|:||.     :..:
Human   182 DVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVT 246

  Fly   234 YYMKQRRALSLLRSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLLTAK-----LDGKVLKER 293
            :::|.    |:.|.:.:|:..:::|::              .|...::.::     ...|.|.:.
Human   247 HFLKN----SIERMKESRLKDKQKHRV--------------DFFQQMIDSQNSKETKSHKALSDL 293

  Fly   294 EIIEEVSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYL 358
            |::.:....||..:|..:..:.|.:|.|:.|.::|||..||...:.........|  .|.||.||
Human   294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYD--ALVQMEYL 356

  Fly   359 ELIIRETLRLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFEN 423
            ::::.|||||:|.|..:.|..:..|:|||..:.|...|::.:.|:.::.||:.:|..|.||...:
Human   357 DMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFS 421

  Fly   424 PTGNVGIEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPA--------VDGLP 476
            ......|:.::.:||.||||.||..:||:..:|..:.:.|:.|...|.        :|.||
Human   422 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	109/464 (23%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	113/480 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810