DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	542	Identity:	147/542 - (27%)
Similarity:	256/542 - (47%)	Gaps:	76/542 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYP-----FVGNLFQFGLKPAEYPKK 60
            :.|:..:.|||.||:.......|| .|:.|.        |.|     .:|::..  :.|.|
Mouse    22 LLLLGASWILARILIQIYAAYRNY-RHLHGF--------PQPPKRNWLMGHVGM--VTPTE---- 71

  Fly    61 VLQYCRKYDFQGFRSLVFL-----QYHMMLSDPAE----------IQNILSSSSLLYKEHL--YS 108
                      ||.:.|..|     |..:|...|..          :::||::|:.:..:.:  ||
Mouse    72 ----------QGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYS 126

  Fly   109 FLRPWLGDGLLTSSGARWLKHQKLYAPAFERSAIEGYLRVVH-RTGGQFVQKLDVLSDTQEVFDA 172
            .|:||||||||.|:|.:|.:|:::..|||..:.::.|:::.: .|.....:...::||.....|.
Mouse   127 ILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLISDGSARLDM 191

  Fly   173 QELVAKCTLDIVCENATGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMK 237
            .|.|:..|||.: :.......|:...::|:...||.:|..:|.:|....:...|.|:.||...|:
Mouse   192 FEHVSLMTLDSL-QKCVFSFDSNCQEKSSEYIAAILELSALVAKRHQQPLMFMDLLYNLTPDGMR 255

  Fly   238 QRRALSLLRSELNRIISQRRHQLAAEN----TCQQGQPINKPFLDVLLTAK-LDGKVLKEREIIE 297
            .|:|.:::....:.:|.:|...|..:.    ...:.:.....|:||||.:| .|||.|.:.:|..
Mouse   256 FRKACNVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLDFIDVLLLSKDEDGKELSDEDIRA 320

  Fly   298 EVSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELII 362
            |..||:|.|||..|:.:|:.||.|:||.|.|::..:|.:.:.......|.:...|.|:.:|.:.|
Mouse   321 EADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELLRGREPEEIEWDDLAQLPFLTMCI 385

  Fly   363 RETLRLYPSVPLIARTNRNPIDI-NGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTG 426
            :|:|||:|.|.:|:|.....|.: :|..:.|....::.:..:.:|...:.||..:.|.||: |..
Mouse   386 KESLRLHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWPDPEVYDPFRFD-PEN 449

  Fly   427 NVGIEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQS 491
            .........:|||||||.||.:.|||.:||..|:..|.||.:||              :|..|:.
Mouse   450 IKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLP--------------DDKEPRR 500

  Fly   492 EYDPVLNIRVTLKSENGIQIRL 513
            :.:      :.|::|.|:.:|:
Mouse   501 QPE------LILRAEGGLWLRV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	129/462 (28%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	135/496 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845218
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650