DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ad1 and zgc:123299

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	XP_021324190.1	Gene:	zgc:123299 / 641477	ZFINID:	ZDB-GENE-051120-33	Length:	501	Species:	Danio rerio

Alignment Length:	540	Identity:	134/540 - (24%)
Similarity:	234/540 - (43%)	Gaps:	71/540 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKP----AEYPKK- 60
            :|.|.:.::.|....|....:  |:.|:....:.||||.     .:.|..|..|    |.|...
Zfish     6 IFYIILYLLAAVFTAFFAYCL--YVHHIHQKYDHIPGPP-----RDNFLLGHSPSLTKALYSDDS 63

  Fly    61 -----VLQYCRKYDFQGFRSLVFLQYHMMLSDPAEIQNILSS-----SSLLYKEHLYSFLRPWLG 115
                 .||:..||. ..:|........:::..|...:.|:.|     ...:|:.....|.:.:||
Zfish    64 LIYDLFLQWAEKYG-PVYRINTLHYVTIVVYCPEATKTIMMSPKYTKDPFVYRRVFNLFGKRFLG 127

  Fly   116 DGLLTS-SGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKC 179
            .||:|: ....|.:.:::..|||..|.:...:........:.:.||:.:::.:......:||...
Zfish   128 YGLITAVDHDIWYRQRRIMDPAFSSSYLRSLISTFDEMSERLMDKLEEIANNKTPAVMHDLVNCV 192

  Fly   180 TLDIVCENATGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLT----SYYMKQRR 240
            |||::|:.|.|.|.:.|..:.|....|: :||  ::..||.:   .|.|||:.    ....:.|.
Zfish   193 TLDVICKVAFGVDLNFLTQKDSPFQNAV-ELC--LKGMTFDV---RDPLFRIIPKNWKLIQQVRE 251

  Fly   241 ALSLLRSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLLTAKLDGKVLKE---REIIEEVSTF 302
            |..|||....:.|..|:  .|.:|    |:.:.|..|..:|.:..:..|...   .::::...||
Zfish   252 ATELLRKTGEKWIQNRK--TAVKN----GEDVPKDILTQILKSAEEQNVTSTEDFEQMLDNFVTF 310

  Fly   303 IFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFG-ENFAGEADLARLDQMHYLELIIRETL 366
            ...|.:..|..:||.:..|.|:.||.::|..|...:.| :......||.:|.   ||..:::|||
Zfish   311 FMAGQETTANQLSFAIMELGRNPEIYKRAKAEVDEVLGTKREISNEDLGKLT---YLSQVLKETL 372

  Fly   367 RLYPSVPLIARTNRNPIDINGTKV-AKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGI 430
            ||||:.|...|.....:.|||.|: ..|:.:....::... ||:|.||..|.|:||:.   |...
Zfish   373 RLYPTAPGTNRWLHEDMIINGIKIPGGCSVMFNSFVSQRL-EKFFKDPLKFDPKRFDE---NAPK 433

  Fly   431 EAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDP 495
            ..:...||:.|||.||.:.|:..:.|.:|::||:|||.                 ..||...:|
Zfish   434 PYYTYYPFALGPRTCIGQVFSQMEAKVVLAKLLQRFEF-----------------SLVPGQSFD- 480

  Fly   496 VLNIRVTLKSENGIQIRLRK 515
             :....||:.::|:...:::
Zfish   481 -IKDTGTLRPKSGVICNIKQ 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	121/458 (26%)
zgc:123299	XP_021324190.1	p450	39..495	CDD:306555	127/499 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820