DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	XP_006524820.1	Gene:	Cyp4f40 / 631304	MGIID:	3645508	Length:	551	Species:	Mus musculus

Alignment Length:	533	Identity:	153/533 - (28%)
Similarity:	253/533 - (47%)	Gaps:	60/533 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FLIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLF--QFGLKP--AEYPKKVL 62
            ||:.|:..||..|. :...::.....:.|.        |.|...|.|  ..|:.|  .|..|:|.
Mouse    50 FLVGISWFLARFLT-QLYTLYAKCQRLCGF--------PQPPKKNWFWGHLGMSPPTEEGMKQVT 105

  Fly    63 QYCRKYDFQGFRS----LVFLQYHMMLSDPAEIQNILSSSSLLYKEH--LYSFLRPWLGDGLLTS 121
            :....|. |||.:    :|.|   :.|..|..|:::||:|:.:..:.  .||||:||||||||.|
Mouse   106 ELVTTYP-QGFMTWLGPIVPL---ITLCHPDIIRSVLSASAAVAPKDDIFYSFLKPWLGDGLLVS 166

  Fly   122 SGARWLKHQKLYAPAFERSAIEGYLRVVH-RTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVC 185
            :|.:|.:|:::..|||..:.::.|:::.: .|.....:.|.:.|......:..|.::..|||.:
Mouse   167 AGDKWNRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWLRLASGGSTRLNMFENISLMTLDTL- 230

  Fly   186 ENATGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELN 250
            :......:|:...:.|....||.:|..:..:|...::...|.|:|||...|:..:|..|:....:
Mouse   231 QKCVFSFNSNCQEKPSQYIAAILELSTLAVKRNEQLLMHVDLLYRLTPDGMRFYKACRLVHDFTD 295

  Fly   251 RIISQRRHQLAAENTCQQGQPINK--------PFLDVLLTAK-LDGKVLKEREIIEEVSTFIFTG 306
            .:|.:||..|....    |..|.|        .|:||||..| .|||.|.:.:|..|..||:|.|
Mouse   296 AVIQERRRTLLKHG----GDDIIKAKAKSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFRG 356

  Fly   307 HDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYPS 371
            ||..|:.:|:.||.|:||.|.|::..:|.:.:..:....|.:...|.|:.:|.:.|:|:|||:|.
Mouse   357 HDTTASGLSWILYNLARHPEHQERCRQEVQELLRDRDPKEIEWDDLAQLPFLTMCIKESLRLHPP 421

  Fly   372 VPLIARTNRNPIDI-NGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKS 435
            |.:::|.....|.: :|..:.|....|:.:....:|...:.||..:.|.||: |...........
Mouse   422 VTMVSRCCTQDISLPDGRIIPKGVICIINIFGTHHNPTVWRDPEVYDPFRFD-PENIQARSPLSF 485

  Fly   436 VPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIR 500
            :|||||||.||.:.|||.:||..|:..|.||.|||                    .:.:|.....
Mouse   486 IPFSAGPRNCIGQTFAMSEMKVALALTLLRFRILP--------------------DDKEPRRKPE 530

  Fly   501 VTLKSENGIQIRL 513
            :.|::|.|:.:|:
Mouse   531 LILRAEGGLWLRV 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	139/454 (31%)
Cyp4f40	XP_006524820.1	p450	79..542	CDD:365848	145/492 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845219
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650