DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ad1 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	531	Identity:	162/531 - (30%)
Similarity:	270/531 - (50%)	Gaps:	44/531 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLIAIAIILATILVFKGVRIFNYIDHMAG---IMEMIPGPT-PYPFVGNLFQFGLKPAEYPKKV 61
            ::::.| :..|.:|:......:|.:.:..|   .|..|||.. .||.:||..||.....::..::
Zfish     7 LYILGI-LFTAVLLLLLASTAYNPLKNYIGKWNEMRPIPGMAGAYPIIGNALQFKTNAGDFFNQI 70

  Fly    62 LQYCRKYDFQGFRSLVFLQY------HMMLSDPAEIQNILSSSSLLYKEHLYSFLRPWLGDGLLT 120
            ::...:.     |.|...:.      .::|.....|:.:||:|..|.|.:.|.||.||||.||||
Zfish    71 IEGTNEN-----RHLPLAKVWVGPVPFLILYHAENIEVVLSNSRHLDKSYSYRFLHPWLGTGLLT 130

  Fly   121 SSGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVC 185
            |:|.:|...:|:..|.|..|.:..:|.|::......:||:..|.| .|.|:....:..|.|||:|
Zfish   131 STGEKWRNRRKMLTPTFHFSILSDFLEVMNEQTDILIQKMQKLED-GEPFNCFNFITLCALDIIC 194

  Fly   186 ENATGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELN 250
            |.|.|:...:.:...|:...::..:.|::.:|..:.....|.::.......:..:.|.:|.|...
Zfish   195 ETAMGKKIYAQSNADSEYVQSVYKMSDIITKRQRAPWLWPDWIYNKLKEGKEHAKRLKILHSFTA 259

  Fly   251 RIISQRRHQLAAE--NTCQQGQPINKPFLDVLL-TAKLDGKVLKEREIIEEVSTFIFTGHDPIAA 312
            .:|.:|...:::|  :...||:...:.|||:|| |...:|:.|...:|.|||.||:|.|||..||
Zfish   260 NVIRERAEFMSSEPDSDSDQGERKRQAFLDMLLKTTYENGQKLSHEDIQEEVDTFMFEGHDTTAA 324

  Fly   313 AISFTLYTLSRHSEIQQKAAEEQRRIFG--ENFAGEADLARLDQMHYLELIIRETLRLYPSVPLI 375
            ::::.|:.:..|.|:|:....|.:.:||  |...|..||.:|   .|||.:|:|:||::|||||.
Zfish   325 SMNWALHLIGSHPEVQKAVQAELQEVFGSSERHVGVEDLKKL---RYLECVIKESLRIFPSVPLF 386

  Fly   376 ARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFSA 440
            ||:......|||.||.|....::...|:..:.:||.:|..|:|||| .|..:.|...:..:||||
Zfish   387 ARSICEACHINGFKVPKGVNAVIIPYALHRDPRYFPEPEEFQPERF-MPENSKGRHPYAYIPFSA 450

  Fly   441 GPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLKS 505
            |||.||.::|||.:.|.:|:.:||.|::...          .|||:..|..|        :.|:.
Zfish   451 GPRNCIGQRFAMMEEKVVLATILRHFDVEAC----------QSREELRPLGE--------LILRP 497

  Fly   506 ENGIQIRLRKR 516
            |.||.|:|::|
Zfish   498 EKGIWIKLQRR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	143/445 (32%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	153/488 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589845
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850