DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	537	Identity:	124/537 - (23%)
Similarity:	232/537 - (43%)	Gaps:	74/537 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVG-------NLFQFGLKPAEYPKKVLQ 63
            :..::.|:|...||....:...:.     ||||.|:||.|       ..|.|.::.|:      :
Zfish    13 LVFLVITLLYMYGVWPHGFFKKLG-----IPGPRPWPFFGTFLSYTKGFFNFDMECAK------K 66

  Fly    64 YCRKYDFQGFRSLVFLQYHMMLSDPAEIQNILSS---SSLLYKEHLYSFLRPWLGDGLLTSSGAR 125
            |.:.:.....|..:     :|::|...|:.|:..   |:...:..:...|...|.||:......|
Zfish    67 YGKVWGIYDGRLPI-----LMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADGISAVKDER 126

  Fly   126 WLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENATG 190
            |.:.:...:|.|....::....:......:|::.:. ..|.::....:|:||..:||:|..::..
Zfish   127 WKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQ-KRDHEQPVKIKEVVAPYSLDVVTSSSFS 190

  Fly   191 QDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELNRIISQ 255
            .|..|:|.........||:.   ::...||.:..|..||...:..:.:.......||.:|...:.
Zfish   191 VDIDSINNPDDPFVTNIKNF---LKFSLFSPLILFLTLFPSIANLLGKMGISVFSRSIMNFFYTA 252

  Fly   256 RRHQLAAENTCQQGQPINKPFLDVLL------------TAKLDGKVLKEREIIEEVSTFIFTGHD 308
            .| ::..|:....|:   ..||.:::            |::...|.|.:.||:.:...||..|::
Zfish   253 LR-KIKDEHKDSNGR---VDFLRLMIQNQIPDDQAKDTTSEQPVKGLTDHEILSQSFIFILGGYE 313

  Fly   309 PIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLA--RLDQMHYLELIIRETLRLYPS 371
            ..:..:||.|:.|:.:.:..:|..||    ..:||..:..::  .|.:|.|||:.|.|::||.|:
Zfish   314 TTSTTLSFLLHNLATNPDCLEKLVEE----IDKNFPLDTPISYDALMKMDYLEMSINESMRLLPT 374

  Fly   372 VPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSV 436
            .|.:.|..:..:::||..:.|.|.|.:....:..:.:.:|.|..|||||| :|........:..:
Zfish   375 APRLERVCKKTVELNGITIPKDTLVAIPTYVLNRDPQLWDSPQEFRPERF-SPENKSEFLQYAFM 438

  Fly   437 PFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVL--NI 499
            ||..|||.||..:||:..:|.|:.:||:.|.:            :..:|..:| .|..||.  .:
Zfish   439 PFGLGPRNCIGMRFALMIVKLLVVKLLQNFSL------------ETCKETQIP-LELTPVFQPKV 490

  Fly   500 RVTLKSENGIQIRLRKR 516
            .:|||      :..|||
Zfish   491 PITLK------LTPRKR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	108/457 (24%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	116/500 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900