DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ad1 and Cyp6a17

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	127/560 - (22%)
Similarity:	226/560 - (40%)	Gaps:	107/560 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNL---------------FQF 50
            |.|:|:.:::.::|||...|...|.....     ||....:|..||:               :.|
  Fly     1 MLLLALIVVILSLLVFAARRRHGYWQRRG-----IPHDEVHPLFGNIKDWPNKRHIAEIFRDYYF 60

  Fly    51 GLKPAEYPKKVLQYCRKYDFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEH--LYSFLRPW 113
            ..|.::||           |.||  ..|.....:::|...::.:|......::..  .|:.:...
  Fly    61 KYKNSDYP-----------FAGF--FFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDP 112

  Fly   114 LGDGLLTSSGARW--LKHQKLYAPAFERSAIEGYLRVVHRTGGQF--VQKLDVLSDTQEVFDAQE 174
            |...|.:..|.:|  |:|:  ..|.|....::....:|.:.|.:.  |.:....:|..:|.:..:
  Fly   113 LSATLFSIEGQKWRHLRHK--LTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVD 175

  Fly   175 LVAKCTLDIVCENATGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQR 239
            |||:.|.|::...|.|.:.:||....::.....|..  :.:.|..:::..|  ||.......:.|
  Fly   176 LVARYTADVIGNCAFGLNCNSLYDPKAEFVSIGKRA--ITEHRYGNMLDIF--LFGFPKLSRRLR 236

  Fly   240 RALSLLRSE------LNRIISQRRHQLAAENTCQQGQPINKPFLDVLLTA--------KLDGKVL 290
            ..|::..:|      :...|..|.......|          .|:|.|:..        ..||  |
  Fly   237 LKLNIQEAEDFYTKIVRETIDYRLRTKEKRN----------DFMDSLIEMYKNEQSGNSEDG--L 289

  Fly   291 KEREIIEEVSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGEN---FAGEADLARL 352
            ...|::.:...|...|.:..:..:.|.||.|:|:.::|.|..||...:||::   |..|.    :
  Fly   290 TFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEG----I 350

  Fly   353 DQMHYLELIIRETLRLYPSVPLIARTNRNPIDINGTK--VAKCTTVIMCLIAMGYNEKYFDDPCT 415
            .:|.|||.::.||||.||.:..:.|...........|  :||.|.|::..:.:.|:...:.:|..
  Fly   351 KEMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEI 415

  Fly   416 FRPERFENPTGNVGIEAFKS---VPFSAGPRRCIAEKFAMYQMKALLSQLLR--RFEILPAVDGL 475
            |:||||.:..    |.|..|   :||..|||.||..:|.|.|....|:.|:|  :|.:.|
  Fly   416 FKPERFTDEE----IAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSP----- 471

  Fly   476 PPGINDHSREDCVPQSEYDPVLNIRVTLKSENGIQIRLRK 515
                     |..:|..    ::...:.:.:||||.:::.|
  Fly   472 ---------ETQIPMK----IVVKNILISAENGIHLKVEK 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	110/478 (23%)
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	112/494 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900