DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and Cyp313a3

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_650170.2	Gene:	Cyp313a3 / 41488	FlyBaseID:	FBgn0038007	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	117/524 - (22%)
Similarity:	218/524 - (41%)	Gaps:	81/524 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQYCRK 67
            |:|:.:......::...|:  |:.|.     .||||...|.:|..|::.:   .|.:|:....:.
  Fly     7 LLAVGVCFWIYFLWSRRRL--YMMHF-----KIPGPMGLPILGIAFEYLI---TYKRKMSIRTKY 61

  Fly    68 YDFQGFRSLVFL--QYHMMLSDPAEIQNILSSSSLLYKEHLYSFLRP---WLGDGLLTSSGARWL 127
            .|..|...||::  ...::..||...:.|..|...|.:..::|  :|   ..|||||:...::|:
  Fly    62 MDIYGSTCLVWVGPTPFVITRDPKIAEEIFLSPECLNRSSIFS--KPVNSCTGDGLLSLEASKWV 124

  Fly   128 KHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENATGQD 192
            ..:|...|||:::.:..:|.:.:......|..||.|....|. ..::.:.:.:..|..:...|
  Fly   125 DRRKNLNPAFKQNVLLSFLPIFNSEAKTLVAFLDSLVGQGEK-KVRDDIVRWSFRIATQTTVG-- 186

  Fly   193 SSSLNGETSDLHGAIKDLCDVVQERTF---SIVKRFDALFRL----------------TSYYMKQ 238
                              .||.::.:|   |::|.::...::                |....:.
  Fly   187 ------------------TDVKKDASFKNDSVLKSYETFMKIIVMNVLLPFTHNKIFSTLGGFET 233

  Fly   239 RRALSLLRSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLLTAKLDGKVLKEREIIEEVSTFI 303
            ::||:  :|.:|::|.....:..........||.....::..:....:|::.:| |:..|..:|:
  Fly   234 QKALA--KSNVNKMIGTIVDKKLMTKPESGSQPEITSVINKAIELHRNGEMSRE-EVQSECCSFV 295

  Fly   304 FTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLA--RLDQMHYLELIIRETL 366
            ....:.....:...|..|:...|.|....:|.:.:|  ..||:.::.  .|.:|.:||.::.|||
  Fly   296 VAAFETTGDTVYHALILLAMFPEHQDTVYQELKELF--PVAGDFEVTYDDLQRMVFLERVVNETL 358

  Fly   367 RLYPSVPLIAR-TNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYF-DDPCTFRPERFENPTGNVG 429
            ||.||||...| |.|:....:|..:.|...:.:.:.|...|..:: .||.:|.|:.| .|.....
  Fly   359 RLIPSVPFTPRETIRDFRLSSGVVIPKGVGIGIDIFATHRNRDHWGTDPSSFNPDHF-LPDNVRD 422

  Fly   430 IEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLR--------RFEILPAVDGL------PPGIN 480
            ...:..:|||.|.|.||..|:.:...|..||::||        |:|.|..||.:      .||:.
  Fly   423 RHPYAYIPFSKGRRNCIGWKYGLMSSKLALSKILRNCKVSTSFRYEDLEFVDNIGMELAQSPGLE 487

  Fly   481 DHSR 484
            .|.|
  Fly   488 FHRR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	104/469 (22%)
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	102/461 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.860