DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and Cyp313a5

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_650168.1	Gene:	Cyp313a5 / 41486	FlyBaseID:	FBgn0038005	Length:	487	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	114/494 - (23%)
Similarity:	213/494 - (43%)	Gaps:	80/494 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQYCRKYD 69
            |.||||....::...|.  ||     :|..:|||..:||:|..|::           ::..||.
  Fly     9 AFAIILCVYFLWSRRRF--YI-----MMLKLPGPMGFPFIGLAFEY-----------IRLKRKI- 54

  Fly    70 FQGFRSLVFLQYH------------MMLSDPAEIQNILSS------SSLLYKEHLYSFLRPWLGD 116
              ..|:::|..|.            ::..:|..:::|.:|      ||::.|.     :...||.
  Fly    55 --RLRTILFKIYGKTVLTWIGLTPVLVTCEPKILEDIFTSPNCSNRSSVVDKA-----ISSCLGL 112

  Fly   117 GLLTSSGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTL 181
            ||||.....|.:.:||..|:|:.:|:..::.|::......|..|....|..::....|| .|.:.
  Fly   113 GLLTLKNNHWNERRKLLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDGGDINLLPEL-NKWSF 176

  Fly   182 DIVCENATGQD----SSSLNGETSDLHGAIKDLCDVVQERTFSIVK---RFDALFRLTSYYMKQR 239
            .|..:...|.:    ::..||...:.:.|:.:|..:      .:|.   |...|.:|.||..::.
  Fly   177 KIAAQITMGDEVRNQANYQNGNLLESYKALNNLIPI------GVVMPWLRNKYLGKLFSYEKRRL 235

  Fly   240 RALSLLRSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLLTAKLDGKVLKEREIIEEVSTFIF 304
            .|.:...:.:..||.::     ..:|....:|   ..:|.:|.....|: |...:::.|.|..||
  Fly   236 EAATQSNAFIKDIIDKK-----LSSTDNSSEP---ALIDRILNLVRIGE-LSYDDVMGEFSNIIF 291

  Fly   305 TGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIF---GENFAGEADLARLDQMHYLELIIRETL 366
            ...|.::..::..|..::...:.|....||...:|   ||..|..|||.:|.:   |:.::.||:
  Fly   292 AASDTLSITVNNVLILMAMFPKYQDNVFEELAEVFPSGGEFEASHADLEKLVK---LDRVLHETM 353

  Fly   367 RLYPSVPLIARTNRNPIDI-NGTKVAKCTTVIMCLIAMGYNEKYFDDPC-TFRPERF--ENPTGN 427
            ||.|:|||:.|...:.|.: ||..:.:..|:::.:.....|:..:.... .|.|:.|  ||....
  Fly   354 RLIPAVPLLIRQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPENKRAR 418

  Fly   428 VGIEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRF 466
               ..:..:|||.|.:.|:..|.::...|..|:::||.:
  Fly   419 ---PPYSYLPFSKGKKTCLGWKLSLISAKLALAKILRNY 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	105/463 (23%)
Cyp313a5	NP_650168.1	p450	33..458	CDD:299894	105/463 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.860