DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and cyp46a1.4

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	XP_005160404.1	Gene:	cyp46a1.4 / 393451	ZFINID:	ZDB-GENE-040426-1224	Length:	501	Species:	Danio rerio

Alignment Length:	518	Identity:	131/518 - (25%)
Similarity:	223/518 - (43%)	Gaps:	71/518 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 YIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKV-----------LQYCRKY-DFQGFRSL 76
            ||.::....:.||||.     .:.|.||..|: ..|.:           ||:..|| ......||
Zfish    27 YIHYVHQKYDHIPGPP-----RDNFLFGHSPS-LTKSMYADDSLIHDLFLQWAEKYGPVYRINSL 85

  Fly    77 VFLQYHMMLSDPAEIQNILSS-----SSLLYKEHLYSFLRPWLGDGLLTS-SGARWLKHQKLYAP 135
            .::.  :::..|...:.||.|     ...:|:.....|.:.:||.||:|: ....|.:.:::..|
Zfish    86 HYIA--IVVHCPEATKTILMSPKYTKDPFVYRRLFNLFGKRFLGYGLITAVDHDIWYRQRRIMDP 148

  Fly   136 AFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENATGQDSSSLNGET 200
            ||..|.:...:........:.:.||:.:::.:......:||...|||::|:.|.|.|.:.|..:.
Zfish   149 AFSSSYLRSLISTFDEMSERLMDKLEEMANNKTPAVMHDLVNCVTLDVICKVAFGVDLNFLAQKD 213

  Fly   201 SDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQ-RRALSLLRSELNRIISQRRHQLAAEN 264
            |....|: :||  :...|..:...|..||......:.| |.|..|||....:.|..|:  .|.:|
Zfish   214 SPFQNAV-ELC--LNGMTVDLRDPFFRLFPKNWKLIHQIRDAAELLRKTGEKWIQNRK--TAVKN 273

  Fly   265 TCQQGQPINKPFLDVLLTAKLDGKVLKE---REIIEEVSTFIFTGHDPIAAAISFTLYTLSRHSE 326
                |:.:.|..|..:|.:..:..|...   .::::...||...|.:..|..:||.:..|.|:.|
Zfish   274 ----GEDVPKDILTQILKSAEEENVNNTDDLEQMLDNFVTFFIAGQETTANQLSFAIMALGRNPE 334

  Fly   327 IQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTNRNPIDINGTKVA 391
            |.::|..|...:.|..  .|.....|.:..||..:::|||||||:.|...|.....:.|||.|:.
Zfish   335 IYKRAKAEVDEVLGTK--REISNEDLGKFTYLSQVLKETLRLYPTAPGTNRWLHEDMVINGIKIP 397

  Fly   392 KCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKS----VPFSAGPRRCIAEKFAM 452
            ...:|:.........||:|.||..|.||||:       :.|.|.    .||:.|||.|:.:.|:.
Zfish   398 GGCSVMFSSYVSQRLEKFFKDPLKFDPERFD-------VNAPKPYYCYFPFALGPRTCLGQVFSQ 455

  Fly   453 YQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLKSENGIQIRLRK 515
            .:.|.:|::||:|||.                 ..||...:|  :....||:.::|:...:::
Zfish   456 MEAKVVLAKLLQRFEF-----------------SLVPGQSFD--IKDTGTLRPKSGVICNIKQ 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	122/459 (27%)
cyp46a1.4	XP_005160404.1	p450	39..495	CDD:278495	128/500 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810