DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and cyp46a1.2

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	XP_009292815.1	Gene:	cyp46a1.2 / 393433	ZFINID:	ZDB-GENE-040426-1184	Length:	501	Species:	Danio rerio

Alignment Length:	522	Identity:	135/522 - (25%)
Similarity:	222/522 - (42%)	Gaps:	79/522 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 YIDHMAGIMEMIPGPTPYPFVGNLFQFGLKP----AEYPKK------VLQYCRKYDFQGFRSLVF 78
            ||.|:....:.||||.     .:.|..|..|    |.|...      .||:..||. ..:|....
Zfish    27 YIHHLHQKYDHIPGPP-----RDNFLLGHSPSLTKAMYSDDSLIHDLFLQWAEKYG-PVYRINTL 85

  Fly    79 LQYHMMLSDPAEIQNILSSSSLLYKEHLYS-----FLRPWLGDGLLTS-SGARWLKHQKLYAPAF 137
            ....:::..|...:.||.|.........||     |.:.:||:||:|: ....|.:.:::..|||
Zfish    86 HYIAILVHCPEATKTILMSPKYAKDPFSYSRLFNLFGKRFLGNGLVTAVDHDIWYRQRRIMDPAF 150

  Fly   138 ERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENATGQDSSSLNGETSD 202
            ..|.:...:........:.:.||:.:::.:......:||...|||::|:.|.|.|.:.|..:.|.
Zfish   151 SSSYLRSLISTFDEMSERLMDKLEEMANNKTPAVMHDLVNCVTLDVICKVAFGVDLNFLTQKDSP 215

  Fly   203 LHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQ----RRALSLLRSELNRIISQRRHQLAAE 263
            ...|| :||    ....::..| |.|||:.....|.    |.|..|||....:.|..|:  .|.:
Zfish   216 FQNAI-ELC----LNGMALDAR-DPLFRIFPKNWKLIQQIRDAAVLLRKTGEKWIQNRK--TAVK 272

  Fly   264 NTCQQGQPINKPFLDVLLTAKLDGKVLKE---------REIIEEVSTFIFTGHDPIAAAISFTLY 319
            |    |:.:.|..|..:|      |:.:|         .::::...||...|.:..|..:||.:.
Zfish   273 N----GEDVPKDILTQIL------KIAEEENVNSSEDLEQMMDNFVTFFIAGQETTANQLSFAIM 327

  Fly   320 TLSRHSEIQQKAAEEQRRIFG-ENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTNRNPI 383
            .|.|:.||.::|..|...:.| :......||.:|.   ||..:::|||||||:.|...|.....:
Zfish   328 ALGRNPEIYKRAKAEVDEVLGTKREISNEDLGKLT---YLSQVLKETLRLYPTAPGTNRWLHEDM 389

  Fly   384 DINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFSAGPRRCIAE 448
            .|||.|:....:|:.........||:|.||..|.||||:.   |.....:...||:.|||.|:.:
Zfish   390 IINGIKIPGGCSVMFSSFVSQRLEKFFKDPLKFDPERFDE---NAPKPYYCYYPFALGPRTCLGQ 451

  Fly   449 KFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLKSENGIQIRL 513
            .|:..:.|.:|::||:|||.                 ..||...:|  :....||:.::|:...:
Zfish   452 VFSQMEAKVVLAKLLQRFEF-----------------SLVPGQSFD--IKDTGTLRPKSGVICNI 497

  Fly   514 RK 515
            ::
Zfish   498 KQ 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	125/463 (27%)
cyp46a1.2	XP_009292815.1	p450	39..495	CDD:278495	131/504 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810