DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ad1 and cyp4t8

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_954686.2	Gene:	cyp4t8 / 387527	ZFINID:	ZDB-GENE-031219-3	Length:	509	Species:	Danio rerio

Alignment Length:	531	Identity:	157/531 - (29%)
Similarity:	267/531 - (50%)	Gaps:	64/531 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIAIAIILATILVF----KGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQ 63
            ||.:|.:|..:.:.    |||:          .||..|||..:...|::.:| .:.....:|:::
Zfish    19 LIFLACLLTVVKLLIVRRKGVK----------TMERFPGPPAHWLFGHVKEF-RQDGHDLEKIVK 72

  Fly    64 YCRKYDFQGF-----RSLVFLQYHMMLSDPAEIQNILSSSSLLYKEHLYSFLRPWLGDGLLTSSG 123
            :...|.| .|     .||..|..|    .|:.::.||:::. ...::.|.|..||||||||.|:|
Zfish    73 WMELYQF-AFPLWFGPSLAVLNIH----HPSYVKTILTTTE-PKDDYAYKFFIPWLGDGLLVSTG 131

  Fly   124 ARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENA 188
            .:|.:|::|..|.|....::.|::::..:....:.|.:|.|.::|.|:..:.|:..|||.:.:.|
Zfish   132 QKWFRHRRLLTPGFHYDVLKPYVKLISDSTKVMLDKWEVHSRSEESFELFKHVSLMTLDSIMKCA 196

  Fly   189 TGQDSS-SLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELNRI 252
            ...:|: ..:..|:....|:.|||.:|..|.........|:|.|:.:..:.|:|.|:..:....:
Zfish   197 FSCNSNCQTDSGTNPYIQAVFDLCHLVNLRFRVFPYHSKAIFHLSPHGYRFRKAASIAHNHTAEV 261

  Fly   253 ISQRRHQLAAENTCQQGQPINK---PFLDVLLTAKLDGKV-LKEREIIEEVSTFIFTGHDPIAAA 313
            |.:|:..|..|.  :||...|:   .|||:||:|:.:.:. |.:.:|..||.||:|.|||..|:.
Zfish   262 IRKRKEVLKMEE--EQGIVKNRRYLDFLDILLSARDEHQQGLSDEDIRAEVDTFMFEGHDTTASG 324

  Fly   314 ISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADL--ARLDQMHYLELIIRETLRLYPSVPLIA 376
            ||:..|.|:.:.|.|:|..:|.::...    |:|.|  ..|:::.|..:.|:|:|||:|.||.|:
Zfish   325 ISWIFYNLACNPEHQEKCRQEIQQALD----GKATLEWEDLNKIPYTTMCIKESLRLHPPVPGIS 385

  Fly   377 RTNRNPID-INGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERF--ENPTGNVGIEAFKSVPF 438
            |....|:. .:|..|.:..|:.:.:..:..|...:::|..|.|.||  || ..|....||  |||
Zfish   386 RKLTKPLTFFDGRTVPEGCTIGVSIYGIHMNSTVWENPYKFDPLRFLPEN-VANRSPHAF--VPF 447

  Fly   439 SAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTL 503
            |||||.||.:.|||.:||..::..|:|:.::...|..|         ..:||          |.|
Zfish   448 SAGPRNCIGQNFAMNEMKVAVALTLKRYYLIKDPDHTP---------KMIPQ----------VVL 493

  Fly   504 KSENGIQIRLR 514
            :|.|||.|:::
Zfish   494 RSLNGIHIKIK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	137/448 (31%)
cyp4t8	NP_954686.2	p450	46..501	CDD:306555	147/489 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.650