DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and Cyp9c1

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	117/530 - (22%)
Similarity:	209/530 - (39%)	Gaps:	101/530 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLIAIAIILATI--LVFK-GVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVL 62
            |..:.::|.:|.|  |::| .|..|.|.....     :....|.|.:||:          |..||
  Fly     1 MVFVELSIFVAFIGLLLYKWSVYTFGYFSKRG-----VAHEKPIPLLGNI----------PWSVL 50

  Fly    63 QYCRKYDFQGFRSLVFLQYHMM------------LSDPAEIQNILSSSSLLYKEHLYSFLRPWLG 115
            .....|........:.|:.|.:            ||||..|:.:...:...:..|     |..:.
  Fly    51 MGKESYIKHSIDLHLRLKQHKVYGVFNLRDPLYYLSDPELIRQVGIKNFDTFTNH-----RKGIT 110

  Fly   116 DG----------LLTSSGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQ---FVQK-LDVLSDT 166
            :|          ||:....||.:.:....|.|....|.....::|....:   |||: ||  :.|
  Fly   111 EGFNDTSVISKSLLSLRDRRWKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLD--AGT 173

  Fly   167 QEVFDAQELVAKCTLDIVCENATGQDSSSLNGETSDLH------------GAIKDLCDVVQERTF 219
            .|: :.::...:.|.|::...|.|...:|.....::..            |.:|.:..::..:..
  Fly   174 SEL-ELKDFFTRYTNDVIATAAFGIQVNSFKDPNNEFFSIGQRISEFTFWGGLKVMLYILMPKLM 237

  Fly   220 SIVK-------RFDALFRLTSYYMKQRRALSLLRSELNRIISQRRHQLAAENTCQQGQPINKPFL 277
            ..::       ..|...:|....||.|:..|::|.::..::.:.:.|..||   |:|...:
  Fly   238 KALRVPVMDMNNVDYFKKLVFGAMKYRKEQSIVRPDMIHLLMEAQRQFKAE---QEGSAES---- 295

  Fly   278 DVLLTAKLDGKVLKEREIIEEVSTFIFTGHDPIAAAISFTLYTLSRHSEIQQK------AAEEQR 336
                .|:.|.....:.:::.:...|...|.:.:|..:|||.|.|..:.|:|:|      |.:||
  Fly   296 ----AAQQDKAEFNDDDLLAQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQ- 355

  Fly   337 RIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTNRNPI---DINGTKVAKCTTVIM 398
              .||.   ..|...|..|.||..::.|:||.:|...::.|...:..   |..|..|.......:
  Fly   356 --LGEK---PLDYDTLMGMKYLNCVVSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDL 415

  Fly   399 CLIAMG---YNEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFSAGPRRCIAEKFAMYQMKALLS 460
            ..|.:|   ::...|.:|..||||||:....: .|..|..:||..|.|.||..:.|:.::|:|:.
  Fly   416 VHINVGALHHDPDNFPEPEQFRPERFDEEHKH-EIRQFTYLPFGVGQRSCIGNRLALMEVKSLIF 479

  Fly   461 QLLRRFEILP 470
            ||:.|:.:.|
  Fly   480 QLVLRYHLKP 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	107/490 (22%)
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	108/489 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900