DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ad1 and Cyp6a8

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	585	Identity:	127/585 - (21%)
Similarity:	212/585 - (36%)	Gaps:	168/585 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPY-------------------------- 41
            |..:|:.|..||.:...|...|.....     ||...|:
  Fly     7 LFQVAVALLAILTYYIHRKLTYFKRRG-----IPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKF 66

  Fly    42 -----PFVGNLFQFGLKPA------EYPKKVLQYCRKYDFQGFRSLVFLQYHMMLSDPAEIQNIL 95
                 ||||  |.|...||      |..|::|    ..||..|
  Fly    67 RESKAPFVG--FFFFQSPAAFVIDLELAKQIL----IKDFSNF---------------------- 103

  Fly    96 SSSSLLYKE-------HLYSFLRPWLGDGLLTSSGARWLKHQKLYAPAFERSAIEGYLRVVHRT- 152
            |:..:.|.|       ||::.            .||:|    :|.......:...|.:::::.|
  Fly   104 SNKGIFYNEKDDPISAHLFNL------------DGAQW----RLLRNKLSSTFTSGKMKLMYPTV 152

  Fly   153 ---GGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENATGQDSSSLNGETSD-LHGAIKDLCDV 213
               ..:|:..:........|.:.::|||:.|:|::...|.|...:||..|.:: |:...:.|.|
  Fly   153 VSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSLVD- 216

  Fly   214 VQERTFSIVKRFDALFR-LTSYYMKQRRALSLLRSE------LNRIISQ----RRHQLAAENTCQ 267
                     ||...|.. ....|.|..|.|.::|:.      .:||:::    |..:....|
  Fly   217 ---------KRHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFYSRIVTETVAVREKEHIKRN--- 269

  Fly   268 QGQPINKPFLDVLLTAKLDGKVLKE----------REIIEEVSTFIFTGHDPIAAAISFTLYTLS 322
                   .|:|:|:..|...::..|          .|::.:...|...|.:..::.:.|.||.|:
  Fly   270 -------DFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELA 327

  Fly   323 RHSEIQQKAAEEQRRIF---GENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTNRNPID 384
            ::.:||.|...|...:.   .:||..|.    ...:.||..::.||||||..||.:.|.......
  Fly   328 KNPDIQDKVRAEVEEVIEQHDQNFTYEC----TKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYV 388

  Fly   385 INGTK---VAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFSAGPRRCI 446
            :.|..   :....:||:...|:.::...:.:|..|||||| :|..:.|..:...:||..|||.||
  Fly   389 VPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERF-SPEESAGRPSVAWLPFGDGPRNCI 452

  Fly   447 AEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDP---VLNIR--VTLKSE 506
            ..:|...|.:..|:.|:|.|:.........|.:             |||   ||.::  :.||.|
  Fly   453 GLRFGQMQARIGLALLIRNFKFSTCSKTPNPLV-------------YDPKSFVLGVKDGIYLKVE 504

Fly 507 506
Fly 505 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	110/509 (22%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	116/545 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900