DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and Cyp46a1

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	XP_006240610.1	Gene:	Cyp46a1 / 362782	RGDID:	1306605	Length:	500	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	139/525 - (26%)
Similarity:	230/525 - (43%)	Gaps:	74/525 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYP--FVGNLFQFGLKPAEYPKKVLQ 63
            :.|:..|::||..|      ...::.......|.|||| |.|  .:|:|..| .|..|...:|||
  Rat     5 LLLLGSAVLLAFGL------CCTFVHRARSRYEHIPGP-PRPSFLLGHLPYF-WKKDEACGRVLQ 61

  Fly    64 -----YCRKYDFQGFRSLVFLQYHMMLSDPAEIQNILSSS-----SLLYKEHLYSFLRPWLGDGL 118
                 :.:||. ...|..||.:..::::.|..::..|.|:     |.:|:.....|.....|.||
  Rat    62 DVFLDWAKKYG-PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRAIQTVFGERLFGQGL 125

  Fly   119 LTSSG-ARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLD 182
            ::... .||.|.:::...||.||::...:...:....|.::.|:..:|.|.....|:::...|:|
  Rat   126 VSECDYGRWYKQRRVMDLAFSRSSLVSLMGTFNEKAEQLMEILEAKADGQTPVSMQDMLTCATID 190

  Fly   183 IVCENATGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYM----KQ----R 239
            |:.:.|.|.::|.|.|....|..|:|.:.:.:.....::.|           :|    ||    |
  Rat   191 ILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASRNTLAK-----------FMPGKRKQLREIR 244

  Fly   240 RALSLLRSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLLTAK---LDGKVLKEREIIEEVST 301
            .::.|||......:.:||..|      ::|:.:....|..:|.|:   .|.:||     ::...|
  Rat   245 ESIRLLRQVGKDWVQRRREAL------KRGEDVPADILTQILKAEEGAQDDEVL-----LDNFVT 298

  Fly   302 FIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETL 366
            |...||:..|..::||:..|||..||..:...|...:.|..  ...|...|.::.||..:::|:|
  Rat   299 FFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSK--RHLDYEDLGRLQYLSQVLKESL 361

  Fly   367 RLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERF----ENPTGN 427
            ||||......|.......|:|.:|...|.::.....||..:.||:||.||.|:||    ..|
  Rat   362 RLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKP--- 423

  Fly   428 VGIEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSE 492
                .|...|||.|.|.||.::||..::|.::::||:|.|.     .|.||.....:|... ...
  Rat   424 ----RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF-----RLVPGQRFGLQEQAT-LKP 478

  Fly   493 YDPVL 497
            .||||
  Rat   479 LDPVL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	124/461 (27%)
Cyp46a1	XP_006240610.1	p450	34..466	CDD:278495	126/470 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810