DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and Cyp3a44

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_796354.1	Gene:	Cyp3a44 / 337924	MGIID:	2449818	Length:	504	Species:	Mus musculus

Alignment Length:	499	Identity:	120/499 - (24%)
Similarity:	225/499 - (45%)	Gaps:	73/499 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIAIAIILATILVFKGVRIFNYIDHMAGIMEM--IPGPTPYPFVGNLFQFGLKPAEYP---KKVL 62
            |:.:||||        |.::.|.....|:.:.  ||||.|.||:|.:..:      |.   |..:
Mouse    12 LVLLAIIL--------VLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNY------YTGIWKFDM 62

  Fly    63 QYCRKYD-----FQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEHLYSFLRPWLGDGLLT-- 120
            :...||.     |.|...|      ::::||..|:|:|....|    .:::..|.:...|:::
Mouse    63 ECYEKYGKTWGLFDGQTPL------LVITDPETIKNVLVKDCL----SVFTNRREFGPVGIMSKA 117

  Fly   121 ---SSGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLD 182
               |....|.:::.|.:|.|....::....|:.:.|...|:.|...::.......::::...::|
Mouse   118 ISISKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEAEKGMPVAMKDVLGAYSMD 182

  Fly   183 IVCENATGQDSSSLNG-ETSDLHGAIKDL-CDVVQERTFSIV--KRFDALFRLTSYYMKQRRALS 243
            ::...:.|.:..|||. |...:..|.|.| .|......||:|  .....::.:.:..|....::.
Mouse   183 VITSTSFGVNVDSLNNPEDPFVEEAKKFLRVDFFDPLLFSVVLFPLLTPVYEMLNICMFPNDSIE 247

  Fly   244 LL-----RSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLLTA------KLDGKVLKEREIIE 297
            ..     |.:.:|:.|.::|::              .||.:::.:      |...|.....||..
Mouse   248 FFKKFVDRMQESRLDSNQKHRV--------------DFLQLMMNSHNNSKDKDSHKAFSNMEITV 298

  Fly   298 EVSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELII 362
            :...||..|::..::.:|||||.|:.|.:||:|...|..:..........|...  :|.||::::
Mouse   299 QSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKALPNKATPTCDTVM--EMEYLDMVL 361

  Fly   363 RETLRLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGN 427
            .|||||||.|..:.|..:..:::||..:.|.:.|::...|:.::.:::.||..|:||||...  |
Mouse   362 NETLRLYPIVTRLERVCKKDVELNGVYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKE--N 424

  Fly   428 VG-IEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILP 470
            .| |:.:..:||..|||.||..:||:..||..::::|:.|...|
Mouse   425 KGSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQP 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	110/462 (24%)
Cyp3a44	NP_796354.1	p450	39..494	CDD:278495	111/464 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900