DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and Cyp4ac3

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	487	Identity:	140/487 - (28%)
Similarity:	240/487 - (49%)	Gaps:	42/487 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 MIPGPTPYPFVGNLFQFGLKPAEYPKKVLQYCRKYDFQGF--RSLVFLQYHMMLSDPAEIQNILS 96
            ::||.|  .|..||....|.||.....:.:...|.:.|.:  ..|...:|:::.::.||  .|..
  Fly    49 VVPGKT--RFGNNLDLLNLTPANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAE--EIFQ 109

  Fly    97 SSSLLYKEHLYSFLRPWLGDGLLTSSGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLD 161
            |:.:..|...|..:||:||||||.|...:|...:|...|||..:.::.:|.:......:|::.||
  Fly   110 STKITTKNMSYELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILD 174

  Fly   162 VLSDTQEVFDAQELVAKCTLDIVCENATGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFD 226
              .:.....:..:::.:.||:.:||.|.|.....:: |.::...||.|...|..:|..:.:..|:
  Fly   175 --KNVGFELELNQIIPQFTLNNICETALGVKLDDMS-EGNEYRKAIHDFEIVFNQRMCNPLMFFN 236

  Fly   227 ALFRLTSYYMKQRRALSLLRSELNRIISQRRHQLAAENTCQQ---GQPINKPFLDVLLTAKLDGK 288
            ..|.|...|.|..|.|..:....:.||.::|.|...:...|.   |:......||.||.|:.:||
  Fly   237 WYFFLFGDYKKYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLAAEAEGK 301

  Fly   289 VLKEREIIEEVSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLD 353
            : ..:.|.:||:||:|.|:|..:.::.|||..|:.|:::|::..||.:.:  .....|..:.:.:
  Fly   302 I-DHQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDL--PEDIDEVSMFQFN 363

  Fly   354 QMHYLELIIRETLRLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRP 418
            ::.:||.:|:|:|||:||.|:|.||......:||..:.|...:.:.:..:..:.::|..|..|.|
  Fly   364 ELIHLECVIKESLRLFPSAPIIGRTCIEESVMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLP 428

  Fly   419 ERFENPTGNVGIEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHS 483
            ||| .|..:|....|..||||||||.||.:||.:.::|.||:.::|.|::|||.          .
  Fly   429 ERF-LPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPAT----------Q 482

  Fly   484 REDCVPQSEYDPVLNIRVTLKSENGIQIRLRK 515
            .||                |..||||.:|.::
  Fly   483 LED----------------LTFENGIVLRTQQ 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	129/438 (29%)
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	140/485 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460532
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000