DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ad1 and Cyp318a1

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	579	Identity:	121/579 - (20%)
Similarity:	235/579 - (40%)	Gaps:	118/579 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQYCRK 67
            |.|...:||.:|.::..:.:..|..:.|..    |....|.:..|....|.|....:||.||  :
  Fly     7 LWACGALLAVLLAWQQRKCWRLIWQLNGWR----GVIQQPVLWLLLCINLHPNSILEKVSQY--R 65

  Fly    68 YDFQ-------GFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEHLYS--FLRPWLGDGLLTSSG 123
            ..||       |.|.|::      :.|||.::.:|::...|.|..|..  |:|    .|||.:.|
  Fly    66 VHFQRPLAVLVGTRVLLY------IDDPAGMECVLNAPECLDKTFLQDGFFVR----RGLLHARG 120

  Fly   124 ARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQ----EVFDAQELVAKCTLDIV 184
            .:|...:|...|||..:.:..:..|.:..|.|.|::....::..    :...|::|:::..|::.
  Fly   121 QKWKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAEDLLSRAVLEVS 185

  Fly   185 CENATGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTS--YYMKQRRALSLLRS 247
            |....|..::....:.:.:..:.|.|.::...|......:...|.||.:  .|.:.::...||..
  Fly   186 CLTIMGTPTNFTQLDDAHIAHSYKRLLEISAVRVVKPWLQIRLLHRLLAPELYEESKKCAKLLED 250

  Fly   248 ELNRIISQRRH----------QLAAENTCQQGQPINKPFLDVLLTAKLDGKVLKEREIIEEVSTF 302
            .:..|:..:..          :.:.|:.....|  .:.|::.:.....:|::..| ||::|..:.
  Fly   251 FVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQ--RRIFIEQIFQLAANGEMTLE-EIMDEAQSM 312

  Fly   303 IFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFA-----GEADLARLDQMHYLELII 362
            :....:.::.:|...|..|:.:.      .:.|||:..|..|     |:..|.:|.|:.||:..:
  Fly   313 VLVSFETVSNSIMLALLCLATNK------GDCQRRLLAEIRALVPDVGQVGLEQLQQLRYLDAFV 371

  Fly   363 RETLRLYPSVPLIARTNRNPIDING----TKVAKCTTVIMCLIAM-------GYNEKYFDDPCTF 416
            .|:|||..:||:..|.......:.|    |.|.:.:.|::....|       |.|.:.||
  Fly   372 SESLRLLATVPMNLRHVSRDFRLAGRQHETIVPQNSIVVLDTFNMQRDERWWGANARQFD----- 431

  Fly   417 RPERF-----------ENPTGNVGIE--------AFKSVPFSAGPRRCIAEKFAMYQMKALLSQL 462
             |:||           .|.:|: |.:        ::..:|||.|.|.||..::.::.||..|.:|
  Fly   432 -PQRFLDQEEEQLSKGHNDSGS-GEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMKVFLVKL 494

  Fly   463 LRRFEILPAVDGLPPGINDHSREDCVPQSEYDP-----VLNIRVTLKSENGIQIRLRKR 516
            :..|:.                     ||:::.     |.||.:..|:.:.|.:.::.:
  Fly   495 ITNFDF---------------------QSDFELEKLQFVENISLKFKNADDILLTIQPK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	107/493 (22%)
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	107/509 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.820