DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ad1 and Cyp4g15

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_572721.1	Gene:	Cyp4g15 / 32093	FlyBaseID:	FBgn0030304	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	594	Identity:	159/594 - (26%)
Similarity:	266/594 - (44%)	Gaps:	126/594 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IILATILVFKGVRIFNYI------DHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYP-KKVLQYC 65
            ::|.|::::       ||      .|:..:...:|||...|.||:||.. :.||... :.|::..
  Fly    20 LLLPTLVLW-------YIYWRLSRAHLYRLAGRLPGPRGLPIVGHLFDV-IGPASSVFRTVIRKS 76

  Fly    66 RKYD-----FQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEHLYSFLRPWLGDGLLTSSGAR 125
            ..::     :.|.:.:||:.      ||.:::.:|||...:.|...|.|.:||||||||.|:|.:
  Fly    77 APFEHIAKMWIGPKLVVFIY------DPRDVELLLSSHVYIDKASEYKFFKPWLGDGLLISTGQK 135

  Fly   126 WLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENATG 190
            |..|:||.||.|..:.::.::.:.:......|:||  .::....||..:.:::.|::|:.|.|.|
  Fly   136 WRSHRKLIAPTFHLNVLKSFIELFNENSRNVVRKL--RAEDGRTFDCHDYMSEATVEILLETAMG 198

  Fly   191 QDSSSLNGETSDLHG-----AIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELN 250
                 ::.:|.|..|     |:..:||::..|..||..|.:.:|.||.||.:|.|.|:::.....
  Fly   199 -----VSKKTQDKSGFEYAMAVMRMCDILHARHRSIFLRNEFVFTLTRYYKEQGRLLNIIHGLTT 258

  Fly   251 RIISQR--------RHQLA--------------------------------AENTCQQGQPI--- 272
            ::|..:        |..||                                .|...::..|:
  Fly   259 KVIRSKKAAFEQGTRGSLAQCELKAAALEREREQNGGVDQTPSTAGSDEKDREKDKEKASPVAGL 323

  Fly   273 -----------------------NKPFLDVLLTAKLDGKVLKEREIIEEVSTFIFTGHDPIAAAI 314
                                   ...|||::|.:..:|.::.:.||.|:|.|.:|.|||..||..
  Fly   324 SYGQSAGLKDDLDVEDNDIGEKKRLAFLDLMLESAQNGALITDTEIKEQVDTIMFEGHDTTAAGS 388

  Fly   315 SFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTN 379
            ||.|..:..|.:||.:...|...|||:: ...|......:|.|||..:.||||:||.||||||..
  Fly   389 SFFLSLMGIHQDIQDRVLAELDSIFGDS-QRPATFQDTLEMKYLERCLMETLRMYPPVPLIAREL 452

  Fly   380 RNPIDINGTK--VAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFSAGP 442
            :..:.:|...  :.:..||.:..:.:..|.|.:.:|..|.|:.| .|........:..|||||||
  Fly   453 QEDLKLNSGNYVIPRGATVTVATVLLHRNPKVYANPNVFDPDNF-LPERQANRHYYAFVPFSAGP 516

  Fly   443 RRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLKSEN 507
            |.|:..|:||.::|.|||.:||.:.:...:                  :|.|..|...:.||.|.
  Fly   517 RSCVGRKYAMLKLKILLSTILRNYRVYSDL------------------TESDFKLQADIILKREE 563

  Fly   508 GIQIRLRKR 516
            |.::||:.|
  Fly   564 GFRVRLQPR 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	144/512 (28%)
Cyp4g15	NP_572721.1	p450	47..542	CDD:278495	144/510 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	7	6.970