DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ad1 and Cyp4d2

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	168/524 - (32%)
Similarity:	275/524 - (52%)	Gaps:	41/524 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQF-GLKPAEYPKKVLQYCRK 67
            :.:.:..||:|      :::::....| ..::|||.|.||:|||..: ||.|.:....|.:..||
  Fly     7 VLLLVAFATLL------LWDFLWRRRG-NGILPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRK 64

  Fly    68 YDFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEHLYSFLRPWLGDGLLTSSGARWLKHQKL 132
            |. :.:|..:..|..:..:||.:|:.:|||...:.|.:||..|..|||||||.|:|.:|...:|:
  Fly    65 YG-RLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKI 128

  Fly   133 YAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENATGQDSSSLN 197
            ..|.|....:|.::.:..:.....|::|...:|.....:...::....|||:.|.|.|...::..
  Fly   129 ITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQK 193

  Fly   198 GETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLT--SYYMKQRRALSLLRSELNRIISQRRHQL 260
            ........|:.|:.:::.:|.....:|.|.:||||  :...:|.:|:.::......||.:||..|
  Fly   194 NPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERRETL 258

  Fly   261 ---AAENTCQQ-----GQPINKPFLDVLLTAKLDGKVLKEREIIEEVSTFIFTGHDPIAAAISFT 317
               :.|.|.::     ||......|||||.:.:||..|.:.:|.|||.||:|.|||...:||||.
  Fly   259 VNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDEDIREEVDTFMFEGHDTTTSAISFC 323

  Fly   318 LYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTNRNP 382
            ||.:|||.|:||:..:|.|.:.||:......|..|.::.::|.:|:|:|||:|.||:|.|.....
  Fly   324 LYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAED 388

  Fly   383 IDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFSAGPRRCIA 447
            ::|.|..:...|...|.:..:..:.:||:.|..||||||:.....  |..:..:|||||||.||.
  Fly   389 VEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQ--IHPYAYIPFSAGPRNCIG 451

  Fly   448 EKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLKSENGIQIR 512
            :||||.:||:.:|:|||.||:||    |.|                :|..::.:.|:|.||:.:.
  Fly   452 QKFAMLEMKSTVSKLLRHFELLP----LGP----------------EPRHSMNIVLRSANGVHLG 496

  Fly   513 LRKR 516
            |:.|
  Fly   497 LKPR 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	153/444 (34%)
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	162/485 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449024
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.800