DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	XP_006241152.1	Gene:	Cyp4f39 / 299566	RGDID:	1308796	Length:	550	Species:	Rattus norvegicus

Alignment Length:	463	Identity:	135/463 - (29%)
Similarity:	226/463 - (48%)	Gaps:	76/463 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 MMLSDPAEIQNILSSSSLL--YKEHLYSFLRPWLGDGLLTSSGARWLKHQKLYAPAFERSAIEGY 145
            ::|..|..|:.:|.:|:.:  ..|..||||:||||||||.|.|.:|.:|::|..|||....::.|
  Rat   107 LVLVHPDYIKPVLGASAAIAPKDEFFYSFLKPWLGDGLLISKGNKWSRHRRLLTPAFHFDILKPY 171

  Fly   146 LRVVHRTGGQFVQKLDVL---------SDTQEVFDAQELVAKCTLDIVCENATGQDSSSLNGETS 201
            :::       |.|.::::         ..:...||..|.|:..|||.: :......||....:.|
  Rat   172 MKI-------FNQSVNIMHAKWRRHLAEGSVTSFDMFEHVSLMTLDSL-QKCVFSYSSDCQEKLS 228

  Fly   202 DLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELNRIISQRR---HQLAAE 263
            |...:|.:|..:|..|.:.:....|.::.||:...:.|:|...:.:....:|.|||   .:|.||
  Rat   229 DYISSIIELSALVVRRQYRLHHYLDFIYYLTADGRRFRQACDTVHNFTTEVIQQRRRALRELGAE 293

  Fly   264 N--TCQQGQPINKPFLDVLLTAK-LDGKVLKEREIIEEVSTFIFTGHDPIAAAISFTLYTLSRHS 325
            .  ..:||:.::  |:||||.|| .:||.|.:.:|..|..||:|.|||..::.:|:.|:.|:::.
  Rat   294 AWLKAKQGKTLD--FIDVLLLAKDEEGKELSDEDIRAEADTFMFEGHDTTSSGLSWALFNLAKYP 356

  Fly   326 EIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTNRNPIDI-NGTK 389
            |.|.|..||.:.:.......|.|...|.|:.:..:.|:|:||.:|.|.||:|.....|.: :|..
  Rat   357 EYQDKCREEIQEVMKGRELEELDWDDLTQLPFTTMCIKESLRQFPPVTLISRRCTEDIKLPDGRI 421

  Fly   390 VAKCTTVIMCLIAM---GYNEKYFDDPCTFRPERFE-------NPTGNVGIEAFKSVPFSAGPRR 444
            :.|   .|:||:::   .||...:.|...:.|.||:       :|.      ||  ||||||||.
  Rat   422 IPK---GIICLVSIYGTHYNPLVWPDSKVYNPYRFDPDIPQQRSPL------AF--VPFSAGPRN 475

  Fly   445 CIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIR----VTLKS 505
            ||.:.|||.:|:.:::..|.||.:                       ..|....:|    :.|::
  Rat   476 CIGQSFAMAEMRVVVALTLLRFRL-----------------------SVDRTRKVRRKPELILRT 517

  Fly   506 ENGIQIRL 513
            |||:.:.:
  Rat   518 ENGLWLNV 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	129/414 (31%)
Cyp4f39	XP_006241152.1	CYP4F	82..523	CDD:410772	135/459 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348376
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650