DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and CYP4A22

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001010969.2	Gene:	CYP4A22 / 284541	HGNCID:	20575	Length:	519	Species:	Homo sapiens

Alignment Length:	525	Identity:	148/525 - (28%)
Similarity:	254/525 - (48%)	Gaps:	55/525 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNL--FQFGLKPAEYPKKVLQY---CR 66
            ::::..:|:.|..:::.:...:...::..|.|..:...|::  ||...:.....::|..:   |.
Human    23 SLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPSACP 87

  Fly    67 KYDFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEH-LYSFLRPWLGDGLLTSSGARWLKHQ 130
            .:.:.|       :..:.|.||..::.||..|.  .|.| .|.||.|.:|.|||..:|..|.:|:
Human    88 YWIWGG-------KVRVQLYDPDYMKVILGRSD--PKSHGSYKFLAPRIGYGLLLLNGQTWFQHR 143

  Fly   131 KLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENA-TGQDSS 194
            ::..|||....::.|:.::..:....:.|.:.|.......:..:.|:..|||.:.::| :.|.|.
Human   144 RMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSI 208

  Fly   195 SLNGETSDLHGAIKDLCDVVQERTFSIVKRF----DALFRLTSYYMKQRRALSLLRSELNRIISQ 255
            .::..:.....||.||..:|    |..::..    |.::.|||......||..|.....:::|..
Human   209 QVDRNSQSYIQAISDLNSLV----FCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQL 269

  Fly   256 RRHQLAAENTCQQ-GQPINKPFLDVLLTAKLD-GKVLKEREIIEEVSTFIFTGHDPIAAAISFTL 318
            |:.||..|...:: .:..:..|||:||.||:: |.:|.::::..||.||:|.|||..|:.||:.|
Human   270 RKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWIL 334

  Fly   319 YTLSRHSEIQQKAAEEQRRIFGENFAGEADLA--RLDQMHYLELIIRETLRLYPSVPLIARTNRN 381
            |.|:.|.:.|::..||...:.|:.    |.:.  .||||.|..:.|:|.|||||.||.|.|....
Human   335 YALATHPKHQERCREEIHGLLGDG----ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELST 395

  Fly   382 PIDI-NGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFSAGPRRC 445
            |:.. :|..:.|...|::.:..:.:|.|.:.:...|.|.||. |.......||  :|||.|.|.|
Human   396 PVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFA-PGSAQHSHAF--LPFSGGSRNC 457

  Fly   446 IAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLKSENGIQ 510
            |.::|||.|:|...:..|.|||:||....:|           :|.:        |:.|||:|||.
Human   458 IGKQFAMNQLKVARALTLLRFELLPDPTRIP-----------IPMA--------RLVLKSKNGIH 503

  Fly   511 IRLRK 515
            :|||:
Human   504 LRLRR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	132/449 (29%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	143/491 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154747
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650