DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ad1 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001129072.1	Gene:	Cyp4v3 / 266761	RGDID:	708530	Length:	525	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	166/536 - (30%)
Similarity:	275/536 - (51%)	Gaps:	60/536 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AIAIILATILVFKGVRIFNYIDHMAGI----MEMIPGPT---PYPFVGN-LFQFGLKP--AEYPK 59
            |:::..||:|:       |.:..:...    .:|.|.|:   .||.||: ||   :||  .|:.:
  Rat    21 AVSVAGATVLL-------NILQMLVSYARKWQQMRPIPSVARAYPLVGHALF---MKPNNTEFFQ 75

  Fly    60 KVLQYCRKYDFQGFRSLVFLQYH------MMLSDPAEIQNILSSSSLLYKEHLYSFLRPWLGDGL 118
            :::||..:     ||.|..::..      :.|.....::.||:||..:.|..:|.||:||||.||
  Rat    76 QIIQYTEE-----FRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSFMYKFLQPWLGLGL 135

  Fly   119 LTSSGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDI 183
            |||:|::|...:|:..|:|..:.:|.:|.|::......|.||: ....||.|:....:..|.|||
  Rat   136 LTSTGSKWRARRKMLTPSFHFTILEDFLDVMNEQANILVNKLE-KHVNQEAFNCFFPITLCALDI 199

  Fly   184 VCENATGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSE 248
            :||.|.|::..:.:...|:....:..:.|::..|.......||..:.:.......::.|..|.:.
  Rat   200 ICETAMGKNIGAQSNGDSEYVRTVYRMSDMIYRRMKMPWFWFDLWYLMFKEGRDHKKGLKSLHTF 264

  Fly   249 LNRIISQRRHQLAAENTC-------QQGQPINKPFLDVLLT-AKLDGKVLKEREIIEEVSTFIFT 305
            .|.:|::|.:...||..|       ...:...|.|||:||: ...:|..|...:|.|||.||:|.
  Rat   265 TNNVIAERVNARKAEQDCIGAGRGPLPSKTKRKAFLDLLLSVTDEEGNKLSHEDIREEVDTFMFE 329

  Fly   306 GHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYP 370
            |||..||||:::||.|..:.|:|:|..:|...:||.:.. ...|..|.::.||:.:|:||||::|
  Rat   330 GHDTTAAAINWSLYLLGSNPEVQRKVDKELDDVFGRSHR-PVTLEDLKKLKYLDCVIKETLRVFP 393

  Fly   371 SVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKS 435
            ||||.||:.....::.|.|::|.|..::...|:..:.:||.||..|:|||| .|..:.|...:..
  Rat   394 SVPLFARSLSEDCEVAGYKISKGTEAVIIPYALHRDPRYFPDPEEFQPERF-FPENSQGRHPYAY 457

  Fly   436 VPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIR 500
            ||||||||.||.:|||:.:.|.:|:.:||.|.|          .::..||:.....:
  Rat   458 VPFSAGPRNCIGQKFAVMEEKTILACILREFWI----------ESNQKREELGLAGD-------- 504

  Fly   501 VTLKSENGIQIRLRKR 516
            :.|:..|||.|:|::|
  Rat   505 LILRPNNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	151/453 (33%)
Cyp4v3	NP_001129072.1	CYP4V	76..515	CDD:410773	146/464 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.750