Protein Alignment Cyp4ad1 and Cyp4a8

DIOPT Version :10

• Sequence 1: NP_610380.1
• Gene: Cyp4ad1 / 35821
• FlyBaseID: FBgn0033292
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_113793.2
• Gene: Cyp4a8 / 266674
• RGDID: 628846
• Length: 508
• Species: Rattus norvegicus
• Alignment Length: 529
• Identity: 151/529 - (28%)
• Similarity: 256/529 - (48%)
• Gaps: 55/529 - (10%)

  Fly     2 FLIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNL------FQFGL-KPAEYPK 59
            ||....::...:|:||..:.:.:...:....:..|.|..:.|.|:.      ||..| :...:|.
  Rat    18 FLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSPPSHWFFGHKIPKDQEFQDILTRVKNFPS 82

  Fly    60 KVLQYCRKYDFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEHLYSFLRPWLGDGLLTSSGA 124
            ...|:.       :.|.|.:|.:    ||..::.||..|. ....|.|.||.||:|.|||..:|.
  Rat    83 ACPQWL-------WGSNVRIQVY----DPDYMKLILGRSD-PKSHHSYRFLAPWIGYGLLLLNGQ 135

  Fly   125 RWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVL---SDTQEVFDAQELVAKCTLDIVCE 186
            .|.:|:::..|||....::.|:.::..:....:.|.:.:   ..|.|:|   :.:...|||.:.:
  Rat   136 TWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQIVGQDSTLEIF---QHITLMTLDTIMK 197

  Fly   187 NATGQDSS-SLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELN 250
            .|..|:.| .|:.:......|::||.::...|..:|..:.|.::.|:|...|.|.|..|.....:
  Rat   198 CAFSQEGSVQLDRKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHTD 262

  Fly   251 RIISQRRHQLAAENTCQQ-GQPINKPFLDVLLTAKLD-GKVLKEREIIEEVSTFIFTGHDPIAAA 313
            ::|..|:.||..|...|: .|.....|||:||.|::: |..|.::::..||.||:|.|||..|:.
  Rat   263 QVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFARIENGSSLSDKDLRAEVDTFMFEGHDTTASG 327

  Fly   314 ISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIART 378
            ||:..|.|:.:.|.||...:|.:.:.|:..:...|  .||:|.|..:.|:|.||:||.|..::|.
  Rat   328 ISWIFYALATNPEHQQGCRKEIQSLLGDGASITWD--DLDKMPYTTMCIKEALRIYPPVTAVSRM 390

  Fly   379 NRNPIDI-NGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFSAGP 442
            ...|:.. :|..:.|..||::....:.:|...:.:|..|.|.||. |..:....:|  :|||.|.
  Rat   391 LSTPVTFPDGRSLPKGITVMLSFYGLHHNPTVWPNPEVFDPYRFA-PESSRHSHSF--LPFSGGA 452

  Fly   443 RRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLP-PGINDHSREDCVPQSEYDPVLNIRVTLKSE 506
            |.||.::|||.::|..::..|.|||:||....:| |          :|          |:.|||:
  Rat   453 RNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPIP----------IP----------RLVLKSK 497

  Fly   507 NGIQIRLRK 515
            |||.:||:|
  Rat   498 NGIYLRLKK 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	CYP4	73..511	CDD:410721	134/445 (30%)
Cyp4a8	NP_113793.2	CYP4B-like	70..503	CDD:410771	139/472 (29%)