DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ad1 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	141/525 - (26%)
Similarity:	240/525 - (45%)	Gaps:	56/525 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQYCRKY--- 68
            ::::..::|.|...:......:|..|:..|||..:...|:..:  ::......||:.:.:::
  Rat    18 SVVILMVIVLKLFSLLLRRQKLARAMDSFPGPPTHWLFGHALE--IQKLGSLDKVVSWAQQFPHA 80

  Fly    69 ------DFQGFRSLVFLQYHMML---SDPAEIQNILSSSSLLYKEHLYSFLRPWLGDGLLTSSGA 124
                  .|.||.::....|...:   .||....             :|.|...|:|.|||...|.
  Rat    81 HPLWFGQFVGFLNIYEPDYAKAVYSRGDPKAAD-------------VYDFFLQWIGKGLLVLDGP 132

  Fly   125 RWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENAT 189
            :|.:|:||..|.|....::.|:.:...:....:.|.:..:...:.||....|....||.:.:...
  Rat   133 KWFQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTF 197

  Fly   190 GQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELNRIIS 254
            |:..|.|....:..:.|:.||..::|:|..|.....|.::.||.:..:..||..:.....:.:|.
  Rat   198 GKGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACKIAHDHTDEVIR 262

  Fly   255 QRRHQLAAE---NTCQQGQPINKPFLDVLLTAKLD-GKVLKEREIIEEVSTFIFTGHDPIAAAIS 315
            ||:..|..|   ...||.:.::  |||:||..:.: |..|.:.|:..||.||:|.|||...:.||
  Rat   263 QRKAALQDEKERKKIQQRRHLD--FLDILLGVRDESGIKLSDAELRAEVDTFMFEGHDTTTSGIS 325

  Fly   316 FTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTNR 380
            :.||.::.:.|.||...||.|.|.|:..:.:.|  .|.:|.||.:.::|..||||.||.:.|...
  Rat   326 WFLYCMALYPEHQQLCREEVRGILGDQDSFQWD--DLAKMTYLTMCMKECFRLYPPVPQVYRQLN 388

  Fly   381 NPID-INGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFSAGPRR 444
            .|:. ::|..:...:.:.:.:.|:..|...:.||..|.|.|| :|....|...|..:|||||||.
  Rat   389 KPVTFVDGRSLPAGSLISLHIYALHRNSTVWPDPEVFDPLRF-SPENAAGRHPFAFMPFSAGPRN 452

  Fly   445 CIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLKSENGI 509
            ||.::|||.:||.:.:..|.|||.  ::|.....|.       |||          :.|:|:|||
  Rat   453 CIGQQFAMNEMKVVTALCLLRFEF--SLDPSKMPIK-------VPQ----------LILRSKNGI 498

  Fly   510 QIRLR 514
            .:.|:
  Rat   499 HLYLK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	126/450 (28%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	136/491 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348664
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650