DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ad1 and Cyp4a2

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	XP_038965182.1	Gene:	Cyp4a2 / 24306	RGDID:	2479	Length:	517	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	156/531 - (29%)
Similarity:	258/531 - (48%)	Gaps:	55/531 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FLIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQYCR 66
            ||:::.::|     ||.|:.:.....:...:|..|. ||..:   |:...||..|: ::||.:..
  Rat    23 FLLSLFLVL-----FKAVQFYLRRQWLLKALEKFPS-TPSHW---LWGHNLKDREF-QQVLTWVE 77

  Fly    67 KYDFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEHLYSFLRPWLGDGLLTSSGARWLKHQK 131
            |:.....:.|......::|.||..::.:|..|.    ...|..|.||:|.|||..:|.:|.:|::
  Rat    78 KFPGACLQWLSGSTARVLLYDPDYVKVVLGRSD----PKPYQSLAPWIGYGLLLLNGKKWFQHRR 138

  Fly   132 LYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENA-TGQDSSS 195
            :..|||....::.|::::..:....:.|.:.|.|.....:....|:..|||.|.:.| :.|.|..
  Rat   139 MLTPAFHYDILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQ 203

  Fly   196 LNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRA-------------LSLLRS 247
            |:..:.....|::||.:::..|..|.......::.::|.....|||             |....|
  Rat   204 LDVNSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTGSVFLLPAFLS 268

  Fly   248 ELNRIISQRRHQLAAENTCQQG-QPINKPFLDVLLTAKL-DGKVLKEREIIEEVSTFIFTGHDPI 310
            ..:.:|..|:.||..|...|:. :..:..|||:||.||: |||.|.:.::..||.||:|.|||..
  Rat   269 LSDGVIKTRKAQLQNEEELQKARKKRHLDFLDILLFAKMEDGKSLSDEDLRAEVDTFMFEGHDTT 333

  Fly   311 AAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLI 375
            |:.||:..|.|:.|.|.|::..||.:.|.|:..:...|  .||||.|..:.|:|.||||..||.:
  Rat   334 ASGISWVFYALATHPEHQERCREEVQSILGDGTSVTWD--HLDQMPYTTMCIKEALRLYSPVPSV 396

  Fly   376 ARTNRNPIDI-NGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFS 439
            :|...:|:.. :|..:.|...|.:.:..:.:|..|:.:|..|.|.|| :|.......|:  :|||
  Rat   397 SRELSSPVTFPDGRSIPKGIRVTILIYGLHHNPSYWPNPKVFDPSRF-SPDSPRHSHAY--LPFS 458

  Fly   440 AGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLK 504
            .|.|.||.::|||.::|..::..|.|||:||....:|           ||..        |:.||
  Rat   459 GGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIP-----------VPMP--------RLVLK 504

  Fly   505 SENGIQIRLRK 515
            |:|||.:||:|
  Rat   505 SKNGIHLRLKK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	134/450 (30%)
Cyp4a2	XP_038965182.1	CYP4B-like	69..512	CDD:410771	139/471 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348478
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650