DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ad1 and Cyp4a29

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001093653.1	Gene:	Cyp4a29 / 230639	MGIID:	3717143	Length:	509	Species:	Mus musculus

Alignment Length:	540	Identity:	156/540 - (28%)
Similarity:	252/540 - (46%)	Gaps:	76/540 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FLIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQYCR 66
            ||..|.:|...:|:||..:.:.....:...:...|.|..:...|:..||  |..|..:.:|:|..
Mouse    18 FLQVIFLIGLLLLLFKAAQHYLRRQWLLRALYQFPSPPSHWLFGHCLQF--KVDEELRWILRYLE 80

  Fly    67 KYDFQGFRSLVFLQY----HMMLS--DPAEIQNILSSSSLLYKEHLYSFLRPWLGDGLLTSSGAR 125
            |  |.|    .||.:    |:.:.  ||..::.||..:.  .|..||.||.||||.||...:|..
Mouse    81 K--FPG----AFLHWIWGSHVFIKVCDPDYMKVILGRAD--PKASLYRFLTPWLGHGLFFLNGDE 137

  Fly   126 WLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLS---DTQEVFDAQELVAKCTLDIVCEN 187
            |.:|::|..|||....::.|:.::..:....::|.:.::   .|.|:|....|:   .||.:.:.
Mouse   138 WFQHRRLLTPAFHYDILKPYVGIMADSVQVMLEKWEQIACQDITLEIFHPISLM---MLDTIMKY 199

  Fly   188 A-TGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELNR 251
            | :.|.|..|:..:.....|:.||.::|..|..::....|.::.|||:..:...|..:.....:|
Mouse   200 AFSYQGSVQLDRSSQAYLQAVSDLNNLVTSRMKNVFLHNDIIYNLTSHSRRTNSACQIAHEHTDR 264

  Fly   252 IISQRRHQLAAENTCQQGQPINK-------PFLDVLLTAKL-DGKVLKEREIIEEVSTFIFTGHD 308
            ::..|:.||      |..:.:.|       .|||:||.::: ||..|.::.:..||.:.:|.|||
Mouse   265 VVKLRKAQL------QDNKSMKKLRGKRCLDFLDILLLSRMDDGSSLSDKALRAEVDSLMFGGHD 323

  Fly   309 PIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVP 373
            ..|:.||:..|.|:.|.:.||:..||.:.:.|:......|  .|.||.|..:.|:|.|||||.:|
Mouse   324 TPASGISWVFYALATHPDHQQRCREEVQSLLGDGSPITWD--HLHQMPYTTMCIKEALRLYPPIP 386

  Fly   374 LIARTNRNPIDI-NGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSV- 436
            .:.|....|:.. :|..:.|..||::...|:.:|.|.:.:|..|.|.||          |..||
Mouse   387 SVGRKLSTPVTFPDGRSLPKGITVLLHFYALHHNPKVWPNPEVFDPSRF----------AMNSVQ 441

  Fly   437 ------PFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDP 495
                  |||.|.|.||.:..||..:|..::..|.|||:||          |.||.         |
Mouse   442 HSHAFLPFSGGSRNCIGKHLAMNVLKVAVALTLLRFELLP----------DPSRV---------P 487

  Fly   496 VLNIRVTLKSENGIQIRLRK 515
            :...::.|||:|||.:.|||
Mouse   488 IPTQQLVLKSKNGIYLHLRK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	134/459 (29%)
Cyp4a29	NP_001093653.1	p450	52..503	CDD:278495	146/500 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845049
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650