DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and Cyp4f13

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_570952.1	Gene:	Cyp4f13 / 170716	MGIID:	2158641	Length:	523	Species:	Mus musculus

Alignment Length:	522	Identity:	154/522 - (29%)
Similarity:	255/522 - (48%)	Gaps:	53/522 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQYCRKYDFQGF 73
            |||.||.:    |:.:.|:.:.:......|.|..|.|:|..  :|..|...:.:.:. .:||...
Mouse    30 ILARILAW----IYAFYDNCSRLRCFPQPPKPSWFWGHLAL--MKNNEESMQFITHL-GHDFHDV 87

  Fly    74 R-SLVFLQYHMM-LSDPAEIQNILSSSSLLYKEH--LYSFLRPWLGDGLLTSSGARWLKHQKLYA 134
            . |.|...|.:: |..|..|..:|.:|:.:..:.  ||.||:||||||||.|:|.:|..|::|..
Mouse    88 HLSWVGPVYPILRLVHPNFIAPLLQASAAVAPKEMTLYGFLKPWLGDGLLMSAGDKWSHHRRLLT 152

  Fly   135 PAFERSAIEGYLRVVHRTGGQFVQKLDVL-SDTQEVFDAQELVAKCTLDIVCENATGQDSSSLNG 198
            |||....::.|:::.:::......|...| |......|..|.::..|||.:.:.....||:....
Mouse   153 PAFHFDILKSYVKIFNKSVNIMHAKWQCLASKGTSRLDMFEHISLMTLDSLQKCIFSVDSNCQES 217

  Fly   199 ETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELNRIISQRRHQLAAE 263
            ::..: .||.:|..:|.:|........|.|:.||:...:.|:|..|:.:..:.:|.:||..|
Mouse   218 DSKYI-AAILELSSLVVKRHRQPFLYLDLLYYLTADGRRFRKACDLVHNFTDAVIKERRSTL--- 278

  Fly   264 NTCQQGQPINK--------PFLDVLLTAKLD-GKVLKEREIIEEVSTFIFTGHDPIAAAISFTLY 319
            ||  ||....|        .|:||||.|:.: ||.|...:|..|..||:|.|||...:|:|:.||
Mouse   279 NT--QGVEFLKAKAKTKTLDFIDVLLMAEDEHGKGLSNEDIRAEADTFMFGGHDTTTSALSWILY 341

  Fly   320 TLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTNRNPID 384
            .|:||.|.|::..:|.:.:..:..:.|.:...|.|:.:|.:.|:|:|||:|.|.||:|.....:.
Mouse   342 NLARHPEYQERCRQEVQELLRDRDSEEIEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCTQDVL 406

  Fly   385 I-NGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERF--ENPTGNVGIEAFKSVPFSAGPRRCI 446
            : :|..:.|....::.:..:.:|...:.||..:.|.||  |||.....: ||  :|||||.|.||
Mouse   407 LPDGRAIPKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPENPQKRSPL-AF--IPFSAGTRNCI 468

  Fly   447 AEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLKSENGIQI 511
            .:.|||.::|..|:..|.||.|||                    .:.:|.....:.|::|.|:.:
Mouse   469 GQTFAMSEIKVALALTLLRFRILP--------------------DDKEPRRKPELILRAEGGLWL 513

  Fly   512 RL 513
            |:
Mouse   514 RV 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	140/450 (31%)
Cyp4f13	NP_570952.1	p450	52..513	CDD:278495	146/492 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845177
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650