Protein Alignment Cyp4ad1 and CYP26A1

DIOPT Version :10

• Sequence 1: NP_610380.1
• Gene: Cyp4ad1 / 35821
• FlyBaseID: FBgn0033292
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_000774.2
• Gene: CYP26A1 / 1592
• HGNCID: 2603
• Length: 497
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 124/517 - (23%)
• Similarity: 218/517 - (42%)
• Gaps: 78/517 - (15%)

  Fly     3 LIAIAI---ILATILVFKGVRIFNYIDHMAG-----IMEMIPGPTPYPFVGNLFQFGLKPAEYPK 59
            |:|.|:   :|..:|....::::: :..::|     .:.:.||...:||.|...|..|:    .:
Human     6 LLASALCTFVLPLLLFLAAIKLWD-LYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQ----RR 65

  Fly    60 KVLQY-CRKYDFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEHLYSFLRPWLGDGLLTS-S 122
            |.||. .|||.|. :::.:|.:..:.:.....::.||.....|...|..:.:|..||.|.|:: .
Human    66 KFLQMKRRKYGFI-YKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLH 129

  Fly   123 GARWLKHQKLYAPAFERSAIEGYLRVV-HRTGGQFVQKLDVLSDTQEVF-DAQELVAKCTLDIV- 184
            .:...:.:|:...||.|.|:|.|:.|: ...|....|.|........|: :.:.|:.:..:.|:
Human   130 DSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILL 194

  Fly   185 -CENATGQDSSSLNGETSDLHGAIKDLCDVVQERT---FS--IVKRFDALFRLTSYYMKQRRALS 243
             ||.....|..|           .:.|.:..:|.|   ||  |...|..|:|    .||.|   :
Human   195 GCEPQLAGDGDS-----------EQQLVEAFEEMTRNLFSLPIDVPFSGLYR----GMKAR---N 241

  Fly   244 LLRSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLLT------AKLDGKVLKEREIIEEVSTF 302
            |:.:.:.:.|   |.::......:.||.. |..|.:|:.      .:||.:.||:..     :..
Human   242 LIHARIEQNI---RAKICGLRASEAGQGC-KDALQLLIEHSWERGERLDMQALKQSS-----TEL 297

  Fly   303 IFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRR---IFGENFAGEADLARLDQMHYLELIIRE 364
            :|.||:..|:|.:..:..|..:..:.||..||.:.   :...|...:.|:..|:|:.|:..:|:|
Human   298 LFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKE 362

  Fly   365 TLRLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVG 429
            ||||.|.||...|......::||.::.|...||..:.......:.|.:...|.|:||..|... .
Human   363 TLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPE-D 426

  Fly   430 IEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFE---------------ILPAVDGLP 476
            ...|..:||..|.|.|:.::||...:|....:|.|..:               :.| ||.||
Human   427 ASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYP-VDNLP 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	CYP4	73..511	CDD:410721	104/438 (24%)
CYP26A1	NP_000774.2	CYP26A1	55..490	CDD:410731	114/467 (24%)