DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ad1 and CYP4B1

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001093242.1	Gene:	CYP4B1 / 1580	HGNCID:	2644	Length:	512	Species:	Homo sapiens

Alignment Length:	534	Identity:	143/534 - (26%)
Similarity:	241/534 - (45%)	Gaps:	82/534 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ILVFKGVRIFNYI---DHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQYCRKY------ 68
            |||...:::.:.:   ..:|..|:..|||..:...|:..:  ::......||:.:..::
Human    21 ILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE--IQETGSLDKVVSWAHQFPYAHPL 83

  Fly    69 ---DFQGFRSLVFLQYHMML---SDPAEIQNILSSSSLLYKEHLYSFLRPWLGDGLLTSSGARWL 127
               .|.||.::....|...:   .||.             ...:|.|...|:|.|||...|.:||
Human    84 WFGQFIGFLNIYEPDYAKAVYSRGDPK-------------APDVYDFFLQWIGRGLLVLEGPKWL 135

  Fly   128 KHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFD--------AQELVAKCTLDIV 184
            :|:||..|.|....::.|:.|...:....:.|.:..:...:.||        |...:.|||.
Human   136 QHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTF--- 197

  Fly   185 CENATGQDSSSL-NGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSE 248
                 |:..:.| :...|..:.|:.||..::|:|..|.....|.::.||.:..:..||..:....
Human   198 -----GRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDH 257

  Fly   249 LNRIISQRRHQLAAENTCQQGQPINK---PFLDVLLTAKLDGKV-LKEREIIEEVSTFIFTGHDP 309
            .:::|.:|:..|..|...::.|  |:   .|||:||.|:.:..: |.:.::..||.||:|.|||.
Human   258 TDQVIRERKAALQDEKVRKKIQ--NRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDT 320

  Fly   310 IAAAISFTLYTLSRHSEIQQKAAEEQRRIFG-ENFAGEADLARLDQMHYLELIIRETLRLYPSVP 373
            ..:.||:.||.::.:.|.|.:..||.|.|.| ::|....||.:   |.||.:.|:|:.||||.||
Human   321 TTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGK---MTYLTMCIKESFRLYPPVP 382

  Fly   374 LIARTNRNPID-INGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERF--ENPTGNVGIEAFKS 435
            .:.|....|:. ::|..:...:.:.|.:.|:..|...:.||..|...||  ||.:..   ..|..
Human   383 QVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKR---HPFAF 444

  Fly   436 VPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIR 500
            :|||||||.||.::|||.:||.:.:..|.|||.     .|.|     ||.         |:...:
Human   445 MPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEF-----SLDP-----SRL---------PIKMPQ 490

  Fly   501 VTLKSENGIQIRLR 514
            :.|:|:||..:.|:
Human   491 LVLRSKNGFHLHLK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	128/462 (28%)
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	137/503 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154800
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650