DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and CYP4A11

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_000769.2	Gene:	CYP4A11 / 1579	HGNCID:	2642	Length:	519	Species:	Homo sapiens

Alignment Length:	527	Identity:	151/527 - (28%)
Similarity:	261/527 - (49%)	Gaps:	51/527 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQY--- 64
            |.|.::::..:|:.|.|:::.:...:...::..|.|..:...|::.:  |:..:..:::.::
Human    19 LQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQE--LQQDQELQRIQKWVET 81

  Fly    65 ----CRKYDFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEH-LYSFLRPWLGDGLLTSSGA 124
                |..:.:.|       :..:.|.||..::.||..|.  .|.| .|.||.||:|.|||..:|.
Human    82 FPSACPHWLWGG-------KVRVQLYDPDYMKVILGRSD--PKSHGSYRFLAPWIGYGLLLLNGQ 137

  Fly   125 RWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENA- 188
            .|.:|:::..|||....::.|:.::..:....:.|.:.|.......:..:.|:..|||.:.:.|
Human   138 TWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAF 202

  Fly   189 TGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELNRII 253
            :.|.|..::..:.....||.||.::|..|..:...:.|.::.|||......||..|.....:::|
Human   203 SHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVI 267

  Fly   254 SQRRHQLAAENTCQQ-GQPINKPFLDVLLTAKLD-GKVLKEREIIEEVSTFIFTGHDPIAAAISF 316
            ..|:.||..|...:: .:..:..|||:||.||:: |.:|.::::..||.||:|.|||..|:.||:
Human   268 QLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISW 332

  Fly   317 TLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLA--RLDQMHYLELIIRETLRLYPSVPLIARTN 379
            .||.|:.|.:.|::..||...:.|:.    |.:.  .||||.|..:.|:|.|||||.||.|.|..
Human   333 ILYALATHPKHQERCREEIHSLLGDG----ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGREL 393

  Fly   380 RNPIDI-NGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFSAGPR 443
            ..|:.. :|..:.|...|::.:..:.:|.|.:.:|..|.|.||. |.......||  :|||.|.|
Human   394 STPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFA-PGSAQHSHAF--LPFSGGSR 455

  Fly   444 RCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLKSENG 508
            .||.::|||.::|...:..|.|||:||          |.:|         .|:...|:.|||:||
Human   456 NCIGKQFAMNELKVATALTLLRFELLP----------DPTR---------IPIPIARLVLKSKNG 501

  Fly   509 IQIRLRK 515
            |.:|||:
Human   502 IHLRLRR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	131/447 (29%)
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	143/489 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154746
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650