Protein Alignment Cyp4ad1 and CYP4A11

DIOPT Version :10

• Sequence 1: NP_610380.1
• Gene: Cyp4ad1 / 35821
• FlyBaseID: FBgn0033292
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 151/527 - (28%)
• Similarity: 261/527 - (49%)
• Gaps: 51/527 - (9%)

  Fly     3 LIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQY--- 64
            |.|.::::..:|:.|.|:::.:...:...::..|.|..:...|::.:  |:..:..:::.::
Human    19 LQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQE--LQQDQELQRIQKWVET 81

  Fly    65 ----CRKYDFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEH-LYSFLRPWLGDGLLTSSGA 124
                |..:.:.|       :..:.|.||..::.||..|.  .|.| .|.||.||:|.|||..:|.
Human    82 FPSACPHWLWGG-------KVRVQLYDPDYMKVILGRSD--PKSHGSYRFLAPWIGYGLLLLNGQ 137

  Fly   125 RWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENA- 188
            .|.:|:::..|||....::.|:.::..:....:.|.:.|.......:..:.|:..|||.:.:.|
Human   138 TWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAF 202

  Fly   189 TGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELNRII 253
            :.|.|..::..:.....||.||.::|..|..:...:.|.::.|||......||..|.....:::|
Human   203 SHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVI 267

  Fly   254 SQRRHQLAAENTCQQ-GQPINKPFLDVLLTAKLD-GKVLKEREIIEEVSTFIFTGHDPIAAAISF 316
            ..|:.||..|...:: .:..:..|||:||.||:: |.:|.::::..||.||:|.|||..|:.||:
Human   268 QLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISW 332

  Fly   317 TLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLA--RLDQMHYLELIIRETLRLYPSVPLIARTN 379
            .||.|:.|.:.|::..||...:.|:.    |.:.  .||||.|..:.|:|.|||||.||.|.|..
Human   333 ILYALATHPKHQERCREEIHSLLGDG----ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGREL 393

  Fly   380 RNPIDI-NGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFSAGPR 443
            ..|:.. :|..:.|...|::.:..:.:|.|.:.:|..|.|.||. |.......||  :|||.|.|
Human   394 STPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFA-PGSAQHSHAF--LPFSGGSR 455

  Fly   444 RCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLKSENG 508
            .||.::|||.::|...:..|.|||:||          |.:|         .|:...|:.|||:||
Human   456 NCIGKQFAMNELKVATALTLLRFELLP----------DPTR---------IPIPIARLVLKSKNG 501

  Fly   509 IQIRLRK 515
            |.:|||:
Human   502 IHLRLRR 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	CYP4	73..511	CDD:410721	137/444 (31%)
CYP4A11	NP_000769.2	CYP4B-like	74..505	CDD:410771	139/465 (30%)