Protein Alignment Cyp4ad1 and CYP3A5

DIOPT Version :9

• Sequence 1: NP_610380.1
• Gene: Cyp4ad1 / 35821
• FlyBaseID: FBgn0033292
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 133/562 - (23%)
• Similarity: 236/562 - (41%)
• Gaps: 128/562 - (22%)

  Fly     3 LIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQYCR- 66
            |:|::::|   |...|.|.......:.     ||||||.|.:||              ||.|.:
Human    14 LLAVSLVL---LYLYGTRTHGLFKRLG-----IPGPTPLPLLGN--------------VLSYRQG 56

  Fly    67 --KYDFQGFRSLVFLQYHMM------------LSDPAEIQNILSSSSLLYKEHLYSFL--RPWLG 115
              |:|.:.::     :|..|            ::||..|:.:      |.|| .||..  |..||
Human    57 LWKFDTECYK-----KYGKMWGTYEGQLPVLAITDPDVIRTV------LVKE-CYSVFTNRRSLG 109

  Fly   116 D-GLLTSS-----GARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQE 174
            . |.:.|:     ...|.:.:.|.:|.|....::....::.:.|...|:.|...::..:....::
Human   110 PVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKD 174

  Fly   175 LVAKCTLDIVCENATGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVK--RFDALFR------- 230
            :....::|::...:.|.:..|||...           |...|.|...:|  ..|.||.
Human   175 IFGAYSMDVITGTSFGVNIDSLNNPQ-----------DPFVESTKKFLKFGFLDPLFLSIILFPF 228

  Fly   231 LTSYY------MKQRRALSLLRSELNRIISQR-----RHQLAAENTCQQGQPINKPFLDVLLTAK 284
            ||..:      :..:..::.|...:||:...|     :|:|              .||.:::.::
Human   229 LTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRL--------------DFLQLMIDSQ 279

  Fly   285 -----LDGKVLKEREIIEEVSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFA 344
                 ...|.|.:.|:..:...|||.|::..::.:|||||.|:.|.::|||..:|...:......
Human   280 NSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAP 344

  Fly   345 GEADLARLDQMHYLELIIRETLRLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKY 409
            ...|  .:.||.||::::.|||||:|....:.||.:..::|||..:.|.:.|::...|:.::.||
Human   345 PTYD--AVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKY 407

  Fly   410 FDDPCTFRPERFENPTGNVGIEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDG 474
            :.:|..||||||.....:  |:.:...||..|||.||..:||:..||..|.::|:.|...|.
Human   408 WTEPEEFRPERFSKKKDS--IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPC--- 467

  Fly   475 LPPGINDHSREDCVPQSEYDPVLNIRVTLKSENGIQIRLRKR 516
                     :|..:|..     |:.:..|:.|..|.:::..|
Human   468 ---------KETQIPLK-----LDTQGLLQPEKPIVLKVDSR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	118/481 (25%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	125/524 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810