Protein Alignment Cyp4ad1 and Cyp4a12b

DIOPT Version :10

• Sequence 1: NP_610380.1
• Gene: Cyp4ad1 / 35821
• FlyBaseID: FBgn0033292
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_758510.2
• Gene: Cyp4a12b / 13118
• MGIID: 3611747
• Length: 508
• Species: Mus musculus
• Alignment Length: 534
• Identity: 145/534 - (27%)
• Similarity: 256/534 - (47%)
• Gaps: 65/534 - (12%)

  Fly     2 FLIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAE---------- 56
            :|...:::...:|:||..:::.:...:....:..|.|..:...|:..   ||..:
Mouse    18 YLQVASVLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHKI---LKDQDLQDILTRIKN 79

  Fly    57 YPKKVLQYCRKYDFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEH-LYSFLRPWLGDGLLT 120
            :|....|:.       :.|.|.:|.:    ||..::.||..|.  .|.| .|.||.||:|.|||.
Mouse    80 FPSACPQWL-------WGSKVRIQVY----DPDYMKLILGRSD--PKAHGSYRFLAPWIGRGLLL 131

  Fly   121 SSGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVL---SDTQEVFDAQELVAKCTLD 182
            ..|..|.:|:::..|||....::.|..::..:....:.|.:.:   ..|.|:|   :.:...|||
Mouse   132 LDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVHVMLDKWEQIVGQDSTLEIF---QHITLMTLD 193

  Fly   183 IVCENATGQDSS-SLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLR 246
            .:.:.|...:.| .|:.:......|::||.::...|..:|..:.|.::|::|.......|..|..
Mouse   194 TIMKCAFSHEGSVQLDRKYKSYIQAVEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANSACQLAH 258

  Fly   247 SELNRIISQRRHQLAAENTCQQGQPINK-PFLDVLLTAKLD-GKVLKEREIIEEVSTFIFTGHDP 309
            ...:::|..||.||..|...::.:...: .|||:||.|::: ||.|.::::..||.||:|.|||.
Mouse   259 DHTDQVIKSRRSQLQDEEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDT 323

  Fly   310 IAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLA--RLDQMHYLELIIRETLRLYPSV 372
            .|:.||:..|.|:.:.|.||:..:|.:.:.|:.    |.:.  .||:|.|..:.|:|.||:||.|
Mouse   324 TASGISWIFYALATNPEHQQRCRKEIQSLLGDG----ASITWNDLDKMPYTTMCIKEALRIYPPV 384

  Fly   373 PLIARTNRNPIDI-NGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSV 436
            |.::|...:|:.. :|..:.|...|::....:.:|...:.:|..|.|.||. |..:....:|  :
Mouse   385 PSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFA-PGSSRHSHSF--L 446

  Fly   437 PFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRV 501
            |||.|.|.||.::|||.::|..::..|.|||:||          |.:|.         |:...|:
Mouse   447 PFSGGARNCIGKQFAMNELKVAVALTLLRFELLP----------DPTRV---------PIPIPRI 492

  Fly   502 TLKSENGIQIRLRK 515
            .|||:|||.:.|:|
Mouse   493 VLKSKNGIHLHLKK 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	CYP4	73..511	CDD:410721	132/447 (30%)
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	134/474 (28%)