DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and Cyp3a13

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus

Alignment Length:	551	Identity:	139/551 - (25%)
Similarity:	240/551 - (43%)	Gaps:	109/551 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IILATILVFKGVRIFNYIDHMAGIMEM--IPGPTPYPFVGNL--FQFGLKPAEYPKKVLQYCRKY 68
            ::|||.||.    ::.|..|..||.:.  ||||.|.||:|.:  :|.|....:     :|..:||
Mouse    13 MLLATSLVL----LYLYGTHSHGIFKKLGIPGPKPLPFLGTILAYQKGFWECD-----IQCHKKY 68

  Fly    69 D-----FQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEHLYSFL-RPWLGD-GLL-----TS 121
            .     :.|.:.:      :.::||..|:.:      |.||...:|. |...|. |:|     .|
Mouse    69 GKMWGLYDGRQPV------LAITDPDIIKTV------LVKECYSTFTNRRRFGPVGILKKAISIS 121

  Fly   122 SGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVL-------------SDTQEVFDAQ 173
            ....|.:.:.|.:|.|....::....:::    ||.   |||             :..:::|.|.
Mouse   122 ENEEWKRIRALLSPTFTSGRLKEMFPIIN----QFT---DVLVRNMRQGLGEGKPTSMKDIFGAY 179

  Fly   174 ELVAKCTLDIVCENATGQDSSSLNGETSDLHGAIKDLC--DVVQERTFSI------VKRFDALFR 230
                  ::|::...:.|.:..|||.........||.|.  |:......|:      ...||||
Mouse   180 ------SMDVITATSFGVNIDSLNNPQDPFVEKIKKLLKFDIFDPLFLSVTLFPFLTPVFDAL-- 236

  Fly   231 LTSYYMKQRRALSLLRSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLLTA-----KLDGKVL 290
              :..:..|..:|...:.:.|:         .||..::.:.....||.:::.:     |...|.|
Mouse   237 --NVSLFPRDVISFFTTSVERM---------KENRMKEKEKQRVDFLQLMINSQNYKTKESHKAL 290

  Fly   291 KEREIIEEVSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQM 355
            .:.||:.:...|||.|::..::|:||.||.|:.|.::|:|..:|.............|  .|.||
Mouse   291 SDVEIVAQSVIFIFAGYETTSSALSFALYLLAIHPDVQKKLQDEIDAALPNKAPATYD--TLLQM 353

  Fly   356 HYLELIIRETLRLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPER 420
            .||::::.|||||||....:.|..:..::|||..:.|.|.|::...|:..:.||:.:|..|||||
Mouse   354 EYLDMVVNETLRLYPIAGRLERVCKTDVEINGLFIPKGTVVMIPTFALHKDPKYWPEPEEFRPER 418

  Fly   421 FENPTGNVGIEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSRE 485
            |.....: .|..:..:||.:|||.||..:||:..||..|.::|:.|.:.|.            :|
Mouse   419 FSKKNQD-SINPYMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPC------------KE 470

  Fly   486 DCVPQSEYDPVLNIRVTLKSENGIQIRLRKR 516
            ..:|..     |:.:..|:.||.:.:::..|
Mouse   471 TEIPLK-----LSKQGLLQPENPLLLKVVSR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	121/473 (26%)
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	128/514 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810