Protein Alignment Cyp4ad1 and CYP4F22

DIOPT Version :9

• Sequence 1: NP_610380.1
• Gene: Cyp4ad1 / 35821
• FlyBaseID: FBgn0033292
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 125/450 - (27%)
• Similarity: 225/450 - (50%)
• Gaps: 51/450 - (11%)

  Fly    83 MMLSDPAEIQNIL-SSSSLLYKEHL-YSFLRPWLGDGLLTSSGARWLKHQKLYAPAFERSAIEGY 145
            ::|..|..|:.:| :|:::..|:.| |.||:||||||||.|.|.:|.:|::|..|||....::.|
Human   107 LVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPY 171

  Fly   146 LRVVHRTGGQFVQKLDVLSDTQEV-FDAQELVAKCTLDIVCENATGQDSSSLNGETSDLHGAIKD 209
            :::.:::......|...|::...| .|..|.::..|||.: :......:|:...:.||...||.:
Human   172 MKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSL-QKCVFSYNSNCQEKMSDYISAIIE 235

  Fly   210 LCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELNRIISQRRHQLAAENT-----CQQG 269
            |..:...|.:.:....|.::..::...:.|:|..::......:|.:||..|..:..     .:||
Human   236 LSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQG 300

  Fly   270 QPINKPFLDVLLTAK-LDGKVLKEREIIEEVSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAE 333
            :.::  |:||||.|: .|||.|.:.:|..|..||:|.|||..::.||:.|:.|:::.|.|:|..|
Human   301 KTLD--FIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCRE 363

  Fly   334 EQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTNRNPIDI-NGTKVAKCTTVI 397
            |.:.:.......|.:...|.|:.:..:.|:|:||.||.|.|::|.....|.: :|..:.|   .|
Human   364 EIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPK---GI 425

  Fly   398 MCLIAM---GYNEKYFDDPCTFRPERF--ENPTGNVGIEAFKSVPFSAGPRRCIAEKFAMYQMKA 457
            :||:::   .:|...:.|...:.|.||  :||...   .....||||||||.||.:.|||.:::.
Human   426 ICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQR---SPLAYVPFSAGPRNCIGQSFAMAELRV 487

  Fly   458 LLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIR----VTLKSENGIQIRL 513
            :::..|.||.:                       ..|....:|    :.|::|||:.:::
Human   488 VVALTLLRFRL-----------------------SVDRTRKVRRKPELILRTENGLWLKV 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	119/401 (30%)
CYP4F22	NP_775754.2	p450	60..524	CDD:278495	125/448 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154632
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650