DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and CYP46A1

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_006659.1	Gene:	CYP46A1 / 10858	HGNCID:	2641	Length:	500	Species:	Homo sapiens

Alignment Length:	519	Identity:	141/519 - (27%)
Similarity:	228/519 - (43%)	Gaps:	62/519 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYP--FVGNLFQFGLKPAEYPKKVLQ 63
            :.|:..|::||..|      ...::.......|.|||| |.|  .:|:|..| .|..|...:|||
Human     5 LLLLGSAVLLAFGL------CCTFVHRARSRYEHIPGP-PRPSFLLGHLPCF-WKKDEVGGRVLQ 61

  Fly    64 -----YCRKYDFQGFRSLVFLQYHMMLSDPAEIQNILSSS-----SLLYKEHLYSFLRPWLGDGL 118
                 :.:||. ...|..||.:..::::.|..::..|.|:     |.:|:.....|.....|.||
Human    62 DVFLDWAKKYG-PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGL 125

  Fly   119 LTSSG-ARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLD 182
            ::... .||.|.:::...||.||::...:...:....|.|:.|:..:|.|.....|:::....:|
Human   126 VSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMD 190

  Fly   183 IVCENATGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQ----RRALS 243
            |:.:.|.|.       |||.|.||.|.|...|:.....|....:.|.:......||    |.::.
Human   191 ILAKAAFGM-------ETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIR 248

  Fly   244 LLRSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLLTAKLDGKVLKEREIIEEVSTFIFTGHD 308
            .|| ::.|...|||.:     ..::|:.:....|..:|.|:...:  .:..:::...||...||:
Human   249 FLR-QVGRDWVQRRRE-----ALKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHE 305

  Fly   309 PIAAAISFTLYTLSRHSEIQQKAAEEQRRIFG-ENFAGEADLARLDQMHYLELIIRETLRLYPSV 372
            ..|..::||:..|||..||..:...|...:.| :.:....||.||   .||..:::|:|||||..
Human   306 TSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRL---QYLSQVLKESLRLYPPA 367

  Fly   373 PLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERF----ENPTGNVGIEAF 433
            ....|.......|:|.:|...|.::.....||..:.||:||.||.|:||    ..|       .|
Human   368 WGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKP-------RF 425

  Fly   434 KSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVL 497
            ...|||.|.|.||.::||..::|.::::||:|.|.     .|.||.....:|... ....||||
Human   426 TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF-----RLVPGQRFGLQEQAT-LKPLDPVL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	126/455 (28%)
CYP46A1	NP_006659.1	p450	34..466	CDD:365848	128/464 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4382
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760