Protein Alignment Cyp4ad1 and CYP3A7-CYP3A51P

DIOPT Version :10

• Sequence 1: NP_610380.1
• Gene: Cyp4ad1 / 35821
• FlyBaseID: FBgn0033292
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_001243426.2
• Gene: CYP3A7-CYP3A51P / 100861540
• HGNCID: 51504
• Length: 535
• Species: Homo sapiens
• Alignment Length: 491
• Identity: 114/491 - (23%)
• Similarity: 214/491 - (43%)
• Gaps: 60/491 - (12%)

  Fly     3 LIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQYCRK 67
            |:|:::||   |...|.|.......:.     ||||||.||:||...|......:..:..:..||
Human    14 LLAVSLIL---LYLYGTRTHGLFKKLG-----IPGPTPLPFLGNALSFRKGYWTFDMECYKKYRK 70

  Fly    68 ----YDFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKE--HLYSFLRP-----WLGDGLLTS 121
                ||.|        |..:.::||..|:.:      |.||  .:::..||     ::.:.:..:
Human    71 VWGIYDCQ--------QPMLAITDPDMIKTV------LVKECYSVFTNRRPFGPVGFMKNAISIA 121

  Fly   122 SGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCE 186
            ....|.:.:.|.:|.|....::..:.::.:.|...|:.|...::|.:....:.:....::|::..
Human   122 EDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITS 186

  Fly   187 NATGQDSSSLNGETSDLHGAIKDLCD-------VVQERTFSIVKRFDALFRLTSYYMKQRRALSL 244
            .:.|....|||..........|.|..       |:..:.|..:........:|.:   .|:.:|.
Human   187 TSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVF---PRKVISF 248

  Fly   245 LRSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLLTAKLD-----GKVLKEREIIEEVSTFIF 304
            |...:.:|         .|...::.|.....||.:::.::..     .|.|.:.|::.:...|||
Human   249 LTKSVKQI---------KEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIF 304

  Fly   305 TGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLY 369
            .|::..::.:||.:|.|:.|.::|||..:|...:.........|...  |:.||::::.|||||:
Human   305 AGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVL--QLEYLDMVVNETLRLF 367

  Fly   370 PSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFK 434
            |....:.|..:..::|||..:.|...|::....:.::.||:.:|..|.||||.....: .|:.:.
Human   368 PVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKD-NIDPYI 431

  Fly   435 SVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILP 470
            ..||.:|||.||..:||:..||..|.::|:.|...|
Human   432 YTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKP 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	CYP4	73..511	CDD:410721	91/417 (22%)
CYP3A7-CYP3A51P	NP_001243426.2	CYP3A	67..492	CDD:410743	96/430 (22%)