DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ad1 and Cyp3a59

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001098630.1	Gene:	Cyp3a59 / 100041449	MGIID:	3769707	Length:	503	Species:	Mus musculus

Alignment Length:	529	Identity:	136/529 - (25%)
Similarity:	241/529 - (45%)	Gaps:	85/529 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IILATILVFKGVRIFNYIDHMAGIMEM--IPGPTPYPFVGNLFQF--GLKPAEYPKKVLQYC-RK 67
            ::|.|.|||    .:.|..:..|:.:.  ||||.|.|..|.:|.:  |:      .|..:.| :|
Mouse    13 VLLVTSLVF----FYIYGTYSHGLFKKLGIPGPKPLPLFGTIFNYFDGM------WKFDEDCYKK 67

  Fly    68 Y-DFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEHLYSFL--RPWLG------DGLLTSSG 123
            | ...||  .|..:..:.:.|| ||..|     :|.|| .||..  ||.||      ..:..|..
Mouse    68 YGKIWGF--YVGPKPILAIMDP-EIIKI-----VLVKE-CYSVFTNRPTLGPVGFLKKSITISED 123

  Fly   124 ARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENA 188
            ..|.:.:.|.:|.|....::....::.:.|...|:.|....:..|..:.:::....::|::...:
Mouse   124 EEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPINMKDIFGAYSMDVITGTS 188

  Fly   189 TGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIV--KRFD-------------ALFRLTSYYMKQ 238
            .|.:..|||...:..           .::|..|:  |.||             .::.:.:..:..
Mouse   189 FGVNIDSLNNPQNPF-----------VQKTKKILKFKIFDPFLLSTILFPFLTPIYEMLNLSIFP 242

  Fly   239 RRALSLLRSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLL-TAKLDG----KVLKEREIIEE 298
            |.:::..:..:.|:   ::.:||::      |.....||.::: |....|    |.|.:.|:..:
Mouse   243 RDSMNFFKKFVKRM---KKERLASK------QKNRVDFLQLMMNTQNSKGQESQKALSDLEMAAQ 298

  Fly   299 VSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIR 363
            ...|||.|:|..:.:||..:|.|:.|.::|:|..:|..|.. .|.|.....|.:| |.||::::.
Mouse   299 AVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTL-PNKAPVTYDALMD-MEYLDMVVN 361

  Fly   364 ETLRLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERF--ENPTG 426
            |:|||||:...:.|.::..::|||..:.|.|.|::.:..:..|.:|:.:|..|.|.||  || .|
Mouse   362 ESLRLYPTAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKEN-EG 425

  Fly   427 NVGIEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVD-GLPPGINDHSREDCVPQ 490
            |  |:.:..:||..|||.|:..:||:..||..:..:|:.|.:.|..: .:|..|   |||. |.|
Mouse   426 N--IDPYIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQIPLKI---SREP-VFQ 484

  Fly   491 SEYDPVLNI 499
            .|...:|.:
Mouse   485 PEKPIILKV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	118/467 (25%)
Cyp3a59	NP_001098630.1	p450	39..493	CDD:278495	128/497 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810