Protein Alignment Cyp4ad1 and Cyp3a59

DIOPT Version :10

• Sequence 1: NP_610380.1
• Gene: Cyp4ad1 / 35821
• FlyBaseID: FBgn0033292
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_001098630.1
• Gene: Cyp3a59 / 100041449
• MGIID: 3769707
• Length: 503
• Species: Mus musculus
• Alignment Length: 529
• Identity: 136/529 - (25%)
• Similarity: 241/529 - (45%)
• Gaps: 85/529 - (16%)

  Fly     8 IILATILVFKGVRIFNYIDHMAGIMEM--IPGPTPYPFVGNLFQF--GLKPAEYPKKVLQYC-RK 67
            ::|.|.|||    .:.|..:..|:.:.  ||||.|.|..|.:|.:  |:      .|..:.| :|
Mouse    13 VLLVTSLVF----FYIYGTYSHGLFKKLGIPGPKPLPLFGTIFNYFDGM------WKFDEDCYKK 67

  Fly    68 Y-DFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEHLYSFL--RPWLG------DGLLTSSG 123
            | ...||  .|..:..:.:.|| ||..|     :|.|| .||..  ||.||      ..:..|..
Mouse    68 YGKIWGF--YVGPKPILAIMDP-EIIKI-----VLVKE-CYSVFTNRPTLGPVGFLKKSITISED 123

  Fly   124 ARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENA 188
            ..|.:.:.|.:|.|....::....::.:.|...|:.|....:..|..:.:::....::|::...:
Mouse   124 EEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPINMKDIFGAYSMDVITGTS 188

  Fly   189 TGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIV--KRFD-------------ALFRLTSYYMKQ 238
            .|.:..|||...:..           .::|..|:  |.||             .::.:.:..:..
Mouse   189 FGVNIDSLNNPQNPF-----------VQKTKKILKFKIFDPFLLSTILFPFLTPIYEMLNLSIFP 242

  Fly   239 RRALSLLRSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLL-TAKLDG----KVLKEREIIEE 298
            |.:::..:..:.|:   ::.:||::      |.....||.::: |....|    |.|.:.|:..:
Mouse   243 RDSMNFFKKFVKRM---KKERLASK------QKNRVDFLQLMMNTQNSKGQESQKALSDLEMAAQ 298

  Fly   299 VSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIR 363
            ...|||.|:|..:.:||..:|.|:.|.::|:|..:|..|.. .|.|.....|.:| |.||::::.
Mouse   299 AVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTL-PNKAPVTYDALMD-MEYLDMVVN 361

  Fly   364 ETLRLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERF--ENPTG 426
            |:|||||:...:.|.::..::|||..:.|.|.|::.:..:..|.:|:.:|..|.|.||  || .|
Mouse   362 ESLRLYPTAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKEN-EG 425

  Fly   427 NVGIEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVD-GLPPGINDHSREDCVPQ 490
            |  |:.:..:||..|||.|:..:||:..||..:..:|:.|.:.|..: .:|..|   |||. |.|
Mouse   426 N--IDPYIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQIPLKI---SREP-VFQ 484

  Fly   491 SEYDPVLNI 499
            .|...:|.:
Mouse   485 PEKPIILKV 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	CYP4	73..511	CDD:410721	115/458 (25%)
Cyp3a59	NP_001098630.1	CYP3A	67..492	CDD:410743	117/462 (25%)