DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ad1 and cyp4f3

DIOPT Version :9

Sequence 1:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001083010.1	Gene:	cyp4f3 / 100037390	ZFINID:	ZDB-GENE-070410-108	Length:	511	Species:	Danio rerio

Alignment Length:	462	Identity:	126/462 - (27%)
Similarity:	220/462 - (47%)	Gaps:	62/462 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 YHMM-LSDPAEIQNIL-SSSSLLYKEHL-YSFLRPWLGDGLLTSSGARWLKHQKLYAPAFERSAI 142
            |:|: |..|..|:::| :|:|:..|:.: |.|::||||:.||..||..|.:|::|..|||....:
Zfish    81 YNMVRLFHPDYIRSLLTASASITLKDRIFYGFMKPWLGNCLLLQSGQEWSRHRRLLTPAFHFDIL 145

  Fly   143 EGYLRVVHRTGGQFVQKLDVLSDT--------QEVFDAQELVAKCTLDIVCENATGQDSSSLNGE 199
            :.|:.:       |.|..:::.|.        :...|..|.::..|||.:.:.....|:.| ..:
Zfish   146 KKYVHI-------FNQSTNIMHDEWRRLLAKGEHSVDMFEQISSLTLDSLLKCTFSCDTHS-QEK 202

  Fly   200 TSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELNRIISQRRHQL---- 260
            ......||.||..::.:|...:...:|.|:..::...:.::|.:::......|:.:||.||
Zfish   203 PRQYISAILDLSRLLVQRQHYLPYHWDWLYWRSAQGRRFQQACAVVHQFTADIVQERRTQLDQQS 267

  Fly   261 ----AAENTCQQGQPINKPFLDVLLTAKLD-GKVLKEREIIEEVSTFIFTGHDPIAAAISFTLYT 320
                ..|||.:..:..|...:|:||.||.| |:.|...||......|:|.|||..|:|:|:..|.
Zfish   268 DPESHPENTGRYRKRKNTDLIDLLLLAKDDKGEGLTNEEIKAHADMFMFAGHDTTASALSWIFYN 332

  Fly   321 LSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTNRNPIDI 385
            |:.:.:.|::...|.|.:..:..........|.|:.:..:.|:|:|||:..|..:.|.....:..
Zfish   333 LAMNQDYQERCRAEVRDLLADRDTHTIGWEDLSQLTFTTMCIKESLRLHSPVLALTRYYSQNMKT 397

  Fly   386 NGTKVAK--CTTVIMCLIAMGY----NEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFSAGPRR 444
            .|..|..  |    :|||:: |    |.:.:.||..|.|.||: |..:........:|||||||.
Zfish   398 PGDCVIPHGC----LCLISI-YGVHRNPQVWPDPLVFDPTRFD-PHNSDSRSPHAFIPFSAGPRN 456

  Fly   445 CIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNI-RVTLKSENG 508
            ||.:.|||.:||.:::..|.||:|||.                 |:    ||..: ::.|::|.|
Zfish   457 CIGQNFAMAEMKVVVALTLARFKILPG-----------------PK----PVRRLYQLVLRAEGG 500

  Fly   509 IQIRLRK 515
            :.:..::
Zfish   501 MILHFQE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	118/414 (29%)
cyp4f3	NP_001083010.1	p450	38..503	CDD:278495	126/456 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010