DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CSN7 and Cops7a

DIOPT Version :9

Sequence 1:	NP_610379.2	Gene:	CSN7 / 35816	FlyBaseID:	FBgn0028836	Length:	278	Species:	Drosophila melanogaster
Sequence 2:	XP_006506224.2	Gene:	Cops7a / 26894	MGIID:	1349400	Length:	380	Species:	Mus musculus

Alignment Length:	260	Identity:	113/260 - (43%)
Similarity:	157/260 - (60%)	Gaps:	13/260 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EKFCVLAKSSTGAALLDVIRQALEAPNVFVFGELLAEPSVLQLKDGPDSKHFETLNLFAYGTYKE 85
            |:|.:||||:.||||..:|.|.||||.|:||||||..|:|.:|.:...:..|..|.:||||||.:
Mouse   116 EQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYAD 180

  Fly    86 YRAQPEKFIELTPAMQKKLQHLTIVSLAIKAKSIPYALLLSELEIDNVRHLEDIIIEAIYADIIH 150
            |.|:......||.|.:.||:||::|:||.|.|.||||:||..|.:.|||.|||::|||:|||::.
Mouse   181 YLAEARNLPPLTDAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLR 245

  Fly   151 GKLFQNTRILEVDYAQGRDIPPGYTGQIVETLQAWVNSCDSVSNCIEMQIKYANAEKSKRLINKE 215
            |.|.|..:.|||||:.||||.......|.:|||.|...|:.|.:.||.|:..||..|.::|..|:
Mouse   246 GSLDQRNQRLEVDYSIGRDIQRQDLSAIAQTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQ 310

  Fly   216 RVEQDLINLKKVLK-------SQTSDSDESMQIDTHGPGTSGGLGQSELRKKPSKLR----NPRS 269
            ::|.::.||||.:|       :.||...|....:...|  :.|..|.:..||.||.:    ||:|
Mouse   311 QIESEVANLKKTIKVTTAAAAAATSQDPEQHLTELREP--ASGTNQRQPSKKASKGKGEKINPQS 373

Fly 270 269
Mouse 374 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN7	NP_610379.2	PAM	96..185	CDD:214803	47/88 (53%)
Cops7a	XP_006506224.2	PINT	190..280	CDD:214509	47/89 (53%)
Cops7a	XP_006506224.2	CSN7a_helixI	269..318	CDD:408191	16/48 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836099
Domainoid	1	1.000	86	1.000	Domainoid score	I8099
eggNOG	1	0.900	-	-		E1_KOG3250
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	208	1.000	Inparanoid score	I3681
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55460
OrthoDB	1	1.010	-	-		D1396757at2759
OrthoFinder	1	1.000	-	-		FOG0003991
OrthoInspector	1	1.000	-	-		otm43238
orthoMCL	1	0.900	-	-		OOG6_102373
Panther	1	1.100	-	-	O	PTHR15350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R257
SonicParanoid	1	1.000	-	-		X3281
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800