DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2121 and Unc93a

DIOPT Version :9

Sequence 1:	NP_001137618.1	Gene:	CG2121 / 35814	FlyBaseID:	FBgn0033289	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_038955786.1	Gene:	Unc93a / 685007	RGDID:	1583290	Length:	454	Species:	Rattus norvegicus

Alignment Length:	459	Identity:	145/459 - (31%)
Similarity:	243/459 - (52%)	Gaps:	27/459 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 KNVVVIGLAFMIHFTAFHGTSNLQSSVNADKALGTTTLAVIYGSLILSNIFLPMTVIRWFGCRLT 143
            |||:|:...|::.|||:.|..|||||:.:...||..||:.:|||::||::|||..:|:..||:.|
  Rat     6 KNVLVVACGFLLLFTAYGGLQNLQSSLYSAHGLGVATLSTLYGSVLLSSMFLPPILIKKCGCKWT 70

  Fly   144 MALALFAYMPYIAAQFYPRFETLIPAALMVGFGGGPLWCSKCTYLSTVSEALTQVRGNKSRKDVN 208
            :..::..|:.:....|:..:.||||.::::|.|..|||.::||||:.:.....:..|...:..||
  Rat    71 IVGSMCCYVVFSLGNFHANWYTLIPTSILLGLGAAPLWSAQCTYLTVIGNLQAEKVGKLGKDVVN 135

  Fly   209 TVKFFGLFFIFYQMAQVWGNLISSSVLTLSAPAAQSAANDSFELEVQRELERNRVAELCGARFCP 273
              ::||:||:.:|.:.||||||||  |.....:.|.|..|...:.             |||:.|.
  Rat   136 --QYFGIFFLIFQSSGVWGNLISS--LVFGKMSMQDAIPDEQLMS-------------CGAKDCL 183

  Fly   274 GVGAEANPNLVPPAPEQIQLLNSIFLTCMAAAVVMMIFGVSSLKRYGVKRGDTGDGMSGLKLLTV 338
             :|..|......|:.:.|..|..|:.:....|::::...:..:|......|:|........||:
  Rat   184 -MGPSATNTTHHPSQQLIYTLLGIYTSSGVLAILLVAVFLEPVKDKLENEGETRSRPLWSTLLS- 246

  Fly   339 TINLLRKRRQILMLPITMFIGLEEAFLAVDFTRSFVACGWGISRIGFAMICFGVANAVAAGIAGA 403
            |..|.|.:|..|::.:.::.|.::.||:.::|:|:|.|..||..:|:.||||....|:.:.:.|.
  Rat   247 TFMLFRDKRLCLLMFLPVYSGFQQGFLSGEYTKSYVTCALGIRFVGYVMICFSAMTALCSLLYGK 311

  Fly   404 LVERIGRVTLAALCAVVNLCLLTYMYTWEAREGDYMSYCTFAAVWGICDGVWLVVVNAFYGILFP 468
            :.:..||:||..|.|.::...:.....|.........:...:.:||:.|.||....|..:|:||.
  Rat   312 ISKYTGRITLYVLGAAIHFSCIVVFLLWHPNPAQLPVFFVLSGLWGMADAVWQTQNNVLFGVLFE 376

  Fly   469 NHLIAAYSNFRLWESTGSVIGYVISSQLCTSTKLVILIIFILVGCVGYGLIEYRFWQ-------- 525
            .:...|::|:||.|:.|.||.:..||.||.||||.||:..:.|..|.||.:|||.::
  Rat   377 ENKEPAFANYRLGEAVGFVIAFGYSSFLCVSTKLYILLGVLSVAMVSYGTVEYREYKAASKVLAA 441

  Fly   526 KQKN 529
            ::||
  Rat   442 EEKN 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2121	NP_001137618.1	MFS	84..>189	CDD:304372	40/104 (38%)
CG2121	NP_001137618.1	MFS_1	<296..476	CDD:284993	45/179 (25%)
Unc93a	XP_038955786.1	MFS_unc93A_like	8..432	CDD:340964	141/442 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338669
Domainoid	1	1.000	87	1.000	Domainoid score	I7832
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54908
OrthoDB	1	1.010	-	-		D1145833at2759
OrthoFinder	1	1.000	-	-		FOG0003220
OrthoInspector	1	1.000	-	-		otm45348
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19444
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2635
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.960