DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdm3 and pou3f3a

DIOPT Version :9

Sequence 1:	NP_001188885.2	Gene:	pdm3 / 35813	FlyBaseID:	FBgn0261588	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_571225.2	Gene:	pou3f3a / 30386	ZFINID:	ZDB-GENE-980526-220	Length:	446	Species:	Danio rerio

Alignment Length:	459	Identity:	121/459 - (26%)
Similarity:	171/459 - (37%)	Gaps:	126/459 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   852 RGSSTVSPKHSP--QGRMGGSGGSTTTGMNLSQHHERHDRLERLERQERHERRSHTPTATATRAS 914
            ||..||....|.  ||.|..|.|    |..||..|:....|..             ..|.|..|:
Zfish    46 RGDPTVKMVQSDFMQGAMAASNG----GHMLSHAHQWVTSLPH-------------AAAAAAAAA 93

  Fly   915 VSSSSSAGHHGGSLPSGRLSPPSSAPSNSAANSISDRGYTSPLFRTHSP------QGHALSLGGS 973
            .::::.||....|.|.|....|......|::|.......|:   ..|.|      |.|..:.||
Zfish    94 AAAAAEAGSPWSSSPVGMAGSPQQQDVKSSSNREDLHSGTA---LHHRPSHLGAHQSHQSAWGG- 154

  Fly   974 PRLERDYLGNGPSSGTATSTSSCGAPTAAGSSATANVLSSINRLNASNGELTITKSLGAPTATAT 1038
                             |:.|.....|.....:..:::.|      ..|..|:...|..|
Zfish   155 -----------------TTASHISTITGGQQQSQQSLIYS------QPGGFTVNGMLNPP----- 191

  Fly  1039 RASSASP---RDDSPGPGPSTSSVSHMQPLKLSPSSRSEPP--------HLSPNGNDNDNDLLMD 1092
             .|...|   |.:||..........|.|          :.|        |...|.:|:.:|  .|
Zfish   192 -GSLVHPGLMRGESPEMDHHHHHHHHQQ----------QHPHHHHHHQHHAGVNSHDSHSD--ED 243

  Fly  1093 SPNEPTINQATTNVVDGIDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICSSA 1157
            :|..                |::::|||.||.||:.||.||..||.||....|..:||:.||
Zfish   244 TPTS----------------DDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTIC--- 289

  Fly  1158 LAAQMYAAQLSTQQQNMFEKLDITPKSAQKIKPVLERWMKEAEESHWNRYKSGQNHLTDYIGVEP 1222
                            .||.|.::.|:..|:||:|.:|::||:.:      :|.....|.|..:
Zfish   290 ----------------RFEALQLSFKNMCKLKPLLNKWLEEADST------TGSPTSIDKIAAQ- 331

  Fly  1223 SKKRKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKNTVRMM 1287
            .:|||:|||........|.:||.:...||..|||.||..|..|:||:|:||||:||..|   ||.
Zfish   332 GRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADNLQLEKEVVRVWFCNRRQKEK---RMT 393

  Fly  1288 SKGM 1291
            ..|:
Zfish   394 PPGV 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdm3	NP_001188885.2	Pou	1108..1200	CDD:304656	31/91 (34%)
pdm3	NP_001188885.2	Homeobox	1228..1281	CDD:278475	24/52 (46%)
pou3f3a	NP_571225.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..43
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..172		16/90 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..248		16/95 (17%)
		POU	242..316	CDD:197673	33/108 (31%)
		Homeobox	337..390	CDD:278475	24/52 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810