DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdm3 and Pou6f2

DIOPT Version :9

Sequence 1:	NP_001188885.2	Gene:	pdm3 / 35813	FlyBaseID:	FBgn0261588	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	XP_036013870.1	Gene:	Pou6f2 / 218030	MGIID:	2443631	Length:	728	Species:	Mus musculus

Alignment Length:	947	Identity:	282/947 - (29%)
Similarity:	378/947 - (39%)	Gaps:	335/947 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 HPHHGHQHHH---------HHPATAAALASLQGLAASVFNSPL-------NLSVGGEPVATTG-- 481
            :||...|.||         ....|..|:.....:.|...:.||       |..:.||..|.|.
Mouse     5 NPHSPFQRHHMMDCDLPAQQDTGTMQAVIGQDPMIAGQVSKPLLSVRSEMNAELRGEDKAATSDS 69

  Fly   482 ----PSVAPTSPTHNGGKSKTAK-GGSSGNGSGGSSANSGTSSAQQQQQPDNPSSSSSPHHPLSA 541
                |.:||..  .|..:...:| .|:.||   ....:.||.. |.|....:|:....|...|:|
Mouse    70 ELNEPLLAPAE--SNDSEDTPSKLFGARGN---TVLPDPGTPD-QHQACQTHPTFPVGPQPLLTA 128

  Fly   542 SSLANVLAAATASPPPSLQAPPASAQMPQLIL----ASGQLVQGVQGAQLLIPTA-----QGI-- 595
            ..||:.:|......||:|..|         ||    .:||| .|.||..|.:|||     ||:
Mouse   129 QQLASAVAGVMPGGPPALNQP---------ILIPFNMAGQL-GGQQGLVLTLPTANLTNIQGLVA 183

  Fly   596 --AVQTILTIPVSPQIPTTEQFLPNAFGAFASYQQQQQQQQQQRDLLPPSLAALQHATALPQLAQ 658
              |...|:|:|:        |.|.......:..||.||.|.||
Mouse   184 AAAAGGIMTLPL--------QNLQATSSLNSQLQQLQQLQLQQ---------------------- 218

  Fly   659 TPTNLLKPNLFSTGVQQLLTALHPELFAAAAATHQQQQQQQQQQVQQQRERERERERERERERER 723
                                              ||||||||||.|||:::
Mouse   219 ----------------------------------QQQQQQQQQQQQQQQQQ-------------- 235

  Fly   724 EREQHLGIGHLPHSHLAADLRRSAERSPTAGSPTGGSPGLAAKGPQPPPPGAAFLLQQQLHIKP- 787
                       |.....:...:.|.::|....||         .|..|||.:     |||...|
Mouse   236 -----------PPPPPTSQHPQPASQAPPQSQPT---------PPHQPPPAS-----QQLPAPPA 275

  Fly   788 ---------ETQTHLHHHLQTQSTSAVSSTLPQISLRHPDELTAPQMDLKPLELSASTSP---PA 840
                     :.|.|.|...|||:                          :|.....|:||   |:
Mouse   276 QLQQATQPQQHQPHSHPQNQTQN--------------------------QPSPTQQSSSPPQKPS 314

  Fly   841 PPPRHHFGHSLRGSSTVSPKHSPQGRMGGSGGSTTTGMNLSQHHERHDRLERLERQERHERRSHT 905
            |.|    ||||  .|.::|.:..|                               ...:...|..
Mouse   315 PSP----GHSL--PSPLTPPNPLQ-------------------------------LVNNPLASQA 342

  Fly   906 PTATATRASVSSSSSAGHHGGSLP--SGRLSP-------------PSSAPSNSAANSISDRGYTS 955
            ..|.|...|::||.:.|:...||.  :|:|..             |:..||:.||:..... ...
Mouse   343 AAAAAAMGSIASSQAFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNPGPSSQAASGTQGL-QVQ 406

  Fly   956 PLFRTHSPQGHALSLGGSPRLERDYLGNG--PSSGTATSTSSCGAP---------TAAGSSATAN 1009
            |:    :||   |......::....:||.  |...|...|.|...|         |:.|.:.|..
Mouse   407 PI----TPQ---LLTNAQGQIIATVIGNQILPVINTQGITLSPIKPGQQLHQSSQTSVGQAGTQG 464

  Fly  1010 VLSSINRLNASNGELTITKSLGAPTATATRASSASPRDDSPGPGPSTSSVSHMQPLKLSPSSRSE 1074
                 |.|:.::|:...:.|   |...|:.:||:|         .|:|::|..|
Mouse   465 -----NLLHLAHGQAATSHS---PVRQASSSSSSS---------SSSSALSVGQ----------- 501

  Fly  1075 PPHLSPNGNDNDNDLLMDSPNEPTINQATTNVVDGIDLDEIKEFAKAFKLRRLSLGLTQTQVGQA 1139
                           |:.:|      |.....|||::|:||:|||||||:|||||||||||||||
Mouse   502 ---------------LVSNP------QTAAGEVDGVNLEEIREFAKAFKIRRLSLGLTQTQVGQA 545

  Fly  1140 LSVTEGPAYSQSAICSSALAAQMYAAQLSTQQQNM-----------------FEKLDITPKSAQK 1187
            ||.||||||||||||...:....:......|:..:                 |||||||||||||
Mouse   546 LSATEGPAYSQSAICRHTILRSHFFLPQEAQENTIASSLTAKLNPGLLYPARFEKLDITPKSAQK 610

  Fly  1188 IKPVLERWMKEAEESHWNRYKSGQNHLTDYIGVEPSKKRKRRTSFTPQALELLNAHFERNTHPSG 1252
            |||||||||.|||.    |:::|..:||::||.||||||||||||||||||:||||||:||||||
Mouse   611 IKPVLERWMAEAEA----RHRAGMQNLTEFIGSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSG 671

  Fly  1253 TEITGLAHQLGYEREVIRIWFCNKRQALKNTVRMMSK 1289
            .|:|.:|.:|.|:|||:|:||||||||||||::.:.:
Mouse   672 QEMTEIAEKLNYDREVVRVWFCNKRQALKNTIKRLKQ 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdm3	NP_001188885.2	Pou	1108..1200	CDD:304656	65/108 (60%)
pdm3	NP_001188885.2	Homeobox	1228..1281	CDD:278475	40/52 (77%)
Pou6f2	XP_036013870.1	Pou	514..623	CDD:419906	65/108 (60%)
Pou6f2	XP_036013870.1	Homeobox	647..701	CDD:395001	41/53 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6967
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004074
OrthoInspector	1	1.000	-	-		otm42420
orthoMCL	1	0.900	-	-		OOG6_109259
Panther	1	1.100	-	-	LDO	PTHR11636
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4954
SonicParanoid	1	1.000	-	-		X5977
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.930